FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078278194> ?p ?o ?g. }

• W2078278194 endingPage "1943" @default.
• W2078278194 startingPage "1936" @default.
• W2078278194 abstract "Abstract Embryonic stem (ES) cells are a promising donor source for transplantation therapy, but several problems must be solved before they can be clinically useful. One of these is the host immune reaction to allogeneic grafts. In this article, we examine the effect of the host immune reaction on survival and differentiation of grafted ES cell–derived neural precursor cells (NPCs). We induced NPCs from mouse ES cells by stromal cell–derived inducing activity and then transplanted them into mouse brains with or without administering the immunosuppressant cyclosporine A (CsA). Two and 8 weeks following transplantation, the accumulation of host‐derived microglia/macrophages and lymphocytes was observed around the graft. This effect was reduced by CsA treatment, although no significant difference in graft volume was observed. These data suggest that an immune response occurs in allografts of ES cell–derived NPCs. Intriguingly, however, the ratio of neurons to astrocytes in the graft was higher in immunosuppressed mice. Because inflammatory or immune cells produce various cytokines, we examined the effect of IL‐1β, IL‐6, IFN‐γ, and TNF‐α on the differentiation of NPCs in vitro. Only IL‐6 promoted glial cell fate, and this effect could be reversed by the addition of an IL‐6 neutralizing antibody. These results suggest that allogeneic ES cell–derived NPCs can cause an immune response by the host brain, but it is not strong enough to reject the graft. More important, activated microglia and lymphocytes can suppress neuronal differentiation of grafted NPCs in vivo by producing cytokines such as IL‐6. © 2008 Wiley‐Liss, Inc." @default.
• W2078278194 created "2016-06-24" @default.
• W2078278194 creator A5001222038 @default.
• W2078278194 creator A5014295440 @default.
• W2078278194 creator A5014405737 @default.
• W2078278194 creator A5043379889 @default.
• W2078278194 creator A5053407094 @default.
• W2078278194 creator A5090124645 @default.
• W2078278194 date "2008-03-11" @default.
• W2078278194 modified "2023-10-17" @default.
• W2078278194 title "Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell–derived neural precursor cells" @default.
• W2078278194 cites W1503270785 @default.
• W2078278194 cites W1592915406 @default.
• W2078278194 cites W1899815911 @default.
• W2078278194 cites W1966476278 @default.
• W2078278194 cites W1968614642 @default.
• W2078278194 cites W1970274794 @default.
• W2078278194 cites W1970632673 @default.
• W2078278194 cites W1970993461 @default.
• W2078278194 cites W1979755285 @default.
• W2078278194 cites W1989639507 @default.
• W2078278194 cites W1991641954 @default.
• W2078278194 cites W1998792937 @default.
• W2078278194 cites W2001402754 @default.
• W2078278194 cites W2006712783 @default.
• W2078278194 cites W2013683961 @default.
• W2078278194 cites W2022329534 @default.
• W2078278194 cites W2023273287 @default.
• W2078278194 cites W2025950643 @default.
• W2078278194 cites W2028185241 @default.
• W2078278194 cites W2041199522 @default.
• W2078278194 cites W2042895002 @default.
• W2078278194 cites W2046898449 @default.
• W2078278194 cites W2047174661 @default.
• W2078278194 cites W2048163917 @default.
• W2078278194 cites W2054552572 @default.
• W2078278194 cites W2063778865 @default.
• W2078278194 cites W2069236638 @default.
• W2078278194 cites W2090804892 @default.
• W2078278194 cites W2091496842 @default.
• W2078278194 cites W2095410611 @default.
• W2078278194 cites W2100400132 @default.
• W2078278194 cites W2110267857 @default.
• W2078278194 cites W2111425451 @default.
• W2078278194 cites W2117961839 @default.
• W2078278194 cites W2136755158 @default.
• W2078278194 cites W2137578050 @default.
• W2078278194 cites W2144307065 @default.
• W2078278194 cites W2150813685 @default.
• W2078278194 cites W2151400960 @default.
• W2078278194 cites W2151517892 @default.
• W2078278194 cites W2158649743 @default.
• W2078278194 cites W2163031226 @default.
• W2078278194 cites W2414844163 @default.
• W2078278194 cites W4255806032 @default.
• W2078278194 cites W76778876 @default.
• W2078278194 doi "https://doi.org/10.1002/jnr.21652" @default.
• W2078278194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18335525" @default.
• W2078278194 hasPublicationYear "2008" @default.
• W2078278194 type Work @default.
• W2078278194 sameAs 2078278194 @default.
• W2078278194 citedByCount "63" @default.
• W2078278194 countsByYear W20782781942012 @default.
• W2078278194 countsByYear W20782781942013 @default.
• W2078278194 countsByYear W20782781942015 @default.
• W2078278194 countsByYear W20782781942016 @default.
• W2078278194 countsByYear W20782781942017 @default.
• W2078278194 countsByYear W20782781942018 @default.
• W2078278194 countsByYear W20782781942019 @default.
• W2078278194 countsByYear W20782781942020 @default.
• W2078278194 countsByYear W20782781942021 @default.
• W2078278194 countsByYear W20782781942022 @default.
• W2078278194 countsByYear W20782781942023 @default.
• W2078278194 crossrefType "journal-article" @default.
• W2078278194 hasAuthorship W2078278194A5001222038 @default.
• W2078278194 hasAuthorship W2078278194A5014295440 @default.
• W2078278194 hasAuthorship W2078278194A5014405737 @default.
• W2078278194 hasAuthorship W2078278194A5043379889 @default.
• W2078278194 hasAuthorship W2078278194A5053407094 @default.
• W2078278194 hasAuthorship W2078278194A5090124645 @default.
• W2078278194 hasConcept C104317684 @default.
• W2078278194 hasConcept C124964019 @default.
• W2078278194 hasConcept C126322002 @default.
• W2078278194 hasConcept C145103041 @default.
• W2078278194 hasConcept C148738053 @default.
• W2078278194 hasConcept C1491633281 @default.
• W2078278194 hasConcept C16930146 @default.
• W2078278194 hasConcept C203014093 @default.
• W2078278194 hasConcept C2776914184 @default.
• W2078278194 hasConcept C2779830541 @default.
• W2078278194 hasConcept C2911091166 @default.
• W2078278194 hasConcept C502942594 @default.
• W2078278194 hasConcept C55493867 @default.
• W2078278194 hasConcept C71924100 @default.
• W2078278194 hasConcept C86803240 @default.
• W2078278194 hasConcept C8891405 @default.
• W2078278194 hasConcept C95444343 @default.
• W2078278194 hasConceptScore W2078278194C104317684 @default.

• next