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• W2078278572 abstract "Background and Aim of the Work . Blau syndrome is an inherited granulomatous inflammatory disorder with clinical findings of uveitis, arthritis, and dermatitis. Although rare, Blau syndrome shares features with the more common diseases sarcoidosis and Crohn's disease. The clinical findings of Blau syndrome are indistinguishable from juvenile sarcoidosis; the mutations of Blau syndrome are on the same gene of chromosome 16 (CARD15) that confers susceptibility to Crohn's disease. The product of this gene is part of the innate immune system. Mycobacterium avium ss. paratuberculosis (MAP) is the putative cause of Crohn's disease and has been implicated as a causative agent of sarcoidosis. Methods . Archival tissues of individuals with Blau syndrome were tested for the presence of MAP. Results . DNA evidence of MAP was detected in all of the tissues. Conclusions . This article finds that MAP is present in Blau syndrome tissue and postulates that it has a causal role. The presence of MAP in Blau syndrome—an autosomal dominant, systemic inflammatory disease—connects genetic and environmental aspects of “autoimmune” disease." @default.
• W2078278572 created "2016-06-24" @default.
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• W2078278572 date "2010-01-01" @default.
• W2078278572 modified "2023-10-14" @default.
• W2078278572 title "Detection of<i>Mycobacterium avium ss. Paratuberculosis</i>in Blau Syndrome Tissues" @default.
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• W2078278572 doi "https://doi.org/10.4061/2010/127692" @default.
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