Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078280108> ?p ?o ?g. }
- W2078280108 abstract "Telomerase, the telomeric DNA reverse transcriptase, plays a key role in the maintenance of telomeres in mammals and is required for immortalization of primary cells. Inexplicably, telomerase activation is sometimes associated with telomere shortening and inhibition leads not only to apoptosis but also increased tumorigenicity in rapidly renewing tissues of mouse and man. This article reviews the current evidence, both in vitro and in vivo, for telomerase function and the potential mechanisms, downstream of telomerase, in telomere signaling involving both the tumor-suppressor p53-dependent and independent pathways." @default.
- W2078280108 created "2016-06-24" @default.
- W2078280108 creator A5066286401 @default.
- W2078280108 date "2000-03-01" @default.
- W2078280108 modified "2023-09-23" @default.
- W2078280108 title "Telomerase: Not Just Black and White, but Shades of Gray" @default.
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- W2078280108 doi "https://doi.org/10.1006/mcbr.2000.0203" @default.
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