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- W2078280511 abstract "Recent studies of the mechanisms by which cellular interactions govern lymphocyte proliferation and differentiation have resulted in discovery of the lymphokines and elucidation of their modes of action. These molecules are peptides or proteins, whose amino acid sequence and physico-chemical properties have been difficult to characterize due to the difficulty in achieving high degrees of purity in the preparations under study. Recently, however, we have described the potent immunobiologic activity of a novel class of molecule, the C8-subsituted guanine ribonucleosides. The observation that these synthetic guanosine derivatives are mitogenic for murine splenic lymphocytes without participation of cyclic GMP1 was followed by description of their capacity to induce polyclonal synthesis and secretion of immunoglobulin in both murine and more recently human B lymphocytes. The mitogenic activity of these nucleoside derivatives was shown to be exerted intracellular2, predominantly on a subpopulation of mature B lymphocytes and to a lesser degree on a subset of immature B cells3. In addition, these agents exhibit powerful adjuvant effects both in vitro and in vivo and provide a T cell-like inductive signal for B cells that enables them to generate antigen-specific responses to T cell-dependent antigens in the absence of T cells4." @default.
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- W2078280511 date "1986-01-01" @default.
- W2078280511 modified "2023-09-25" @default.
- W2078280511 title "Enhancement of T Cell Proliferation and Differentiation by 8-Mercaptoguanosine" @default.
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- W2078280511 doi "https://doi.org/10.1007/978-1-4684-1248-2_69" @default.
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