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• W2078281845 abstract "Abstract: The effect of the selective oestrogen receptor modulator, toremifene, to inhibit ovariectomy-induced bone loss was studied in rats. The oral doses were 0.3, 3.0 or 30 mg/kg/day for 2 months. 17β-oestradiol (5 μg/kg/day, subcutaneously) was used as positive control. One group was also treated with a combination of 17β-oestradiol (5 μg/kg) and toremifene (3.0 mg/kg). Biochemical markers were urinary hydroxyproline and calcium (adjusted with urinary creatinine levels) and the serum level of pyridinoline cross-linked carboxy terminal telopeptide, a bone specific collagen breakdown product. The femoral and sternal trabecular bone thickness served as histological parameters. Ovarectomy increased the levels of hydroxyproline and pyrodinoline and decreased the trabecular bone thickness compared to the sham-operated control group. This was inhibited by both test compounds but 17β-oestradiol was more efficient. Toremifene did not reverse the ovariectomy-induced reduction of urinary calcium but inhibited the 17β-oestradiol-related increase. When administered together with oestradiol, toremifene did not reverse the positive effect of 17β-oestradiol on bone, however toremifene reversed the oestradiol-related uterothrophic effects. These findings indicate that the antagonistic features of toremifene dominate in the rat uterus the agonistic properties do in the bone." @default.
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• W2078281845 date "1999-02-01" @default.
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• W2078281845 title "The Effect of Toremifene on Bone and Uterine Histology and on Bone Resorption in Ovariectomised Rats" @default.
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• W2078281845 doi "https://doi.org/10.1111/j.1600-0773.1999.tb00877.x" @default.
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