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- W2078283375 endingPage "353" @default.
- W2078283375 startingPage "344" @default.
- W2078283375 abstract "Apnea, the cessation of breathing, is a common physiological and pathophysiological phenomenon. Among the different forms of apnea, obstructive sleep apnea (OSA) is clinically the most prominent manifestation. OSA is characterized by repetitive airway occlusions that are typically associated with peripheral airway obstructions. However, it would be an oversimplification to conclude that OSA is caused by peripheral obstructions. OSA is the result of a dynamic interplay between chemo- and mechanosensory reflexes, neuromodulation, behavioral state and the differential activation of the central respiratory network and its motor outputs. This interplay has numerous neuronal and cardiovascular consequences that are initially adaptive but in the long-term become major contributors to morbidity and mortality. Not only OSA, but also central apneas (CA) have multiple, and partly overlapping mechanisms. In OSA and CA the underlying mechanisms are neither exclusively peripheral nor exclusively central in origin. This review discusses the complex interplay of peripheral and central nervous components that characterizes the cessation of breathing." @default.
- W2078283375 created "2016-06-24" @default.
- W2078283375 creator A5004128762 @default.
- W2078283375 creator A5010756785 @default.
- W2078283375 creator A5029663876 @default.
- W2078283375 creator A5031114280 @default.
- W2078283375 creator A5064414704 @default.
- W2078283375 creator A5079411871 @default.
- W2078283375 creator A5084887258 @default.
- W2078283375 date "2013-11-01" @default.
- W2078283375 modified "2023-10-06" @default.
- W2078283375 title "Central and peripheral factors contributing to obstructive sleep apneas" @default.
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