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• W2078286637 endingPage "846" @default.
• W2078286637 startingPage "838" @default.
• W2078286637 abstract "ABSTRACT Vacuum Assisted Closure ® brand Negative Pressure Wound Therapy (V.A.C. ® NPWT) has been shown to be an effective therapeutic option for the treatment of recalcitrant wounds; however, the mechanism of action at the cellular level remains to be elucidated. Here, we examined the effects of negative pressure wound therapy, manifolded with two different dressings, on fibroblast viability, chemotactic signaling, and proliferation in a fibrin clot matrix. Fibroblasts were grown in a three‐dimensional fibrin matrix and were treated for 48 hours with either V.A.C. ® NPWT and GranuFoam ® Dressing, or with gauze under suction, or as static controls without negative pressure or dressings. Cells treated by gauze under suction showed significantly greater cell death and stimulated less migration and proliferation than static and V.A.C. ® NPWT‐treated cells ( p <0.05). Apoptosis was also significantly higher in gauze under suction than in static treatments. These results indicate that the dressing material has a significant effect on cell response following negative pressure wound therapy. The ability to support cell growth, stimulate chemotaxis, and proliferation without increasing apoptosis may provide an insight into the mechanisms of action of V.A.C. ® NPWT." @default.
• W2078286637 created "2016-06-24" @default.
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• W2078286637 creator A5018337894 @default.
• W2078286637 creator A5059860419 @default.
• W2078286637 creator A5071820949 @default.
• W2078286637 date "2007-10-03" @default.
• W2078286637 modified "2023-10-15" @default.
• W2078286637 title "Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix" @default.
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• W2078286637 doi "https://doi.org/10.1111/j.1524-475x.2007.00287.x" @default.
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