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• W2078287186 abstract "Primary cultures of cerebellar neurons obtained from 7–9-day-old rats and grown 7–9 days in vitro (DIV) were used to study the effects of Na+ and Ca++ on K+-evoked taurine release. These cultures, made up largely of granule neurons (90%) and inhibitory interneurons (5–7%), produced a dose-dependent, depolarization-evoked taurine release that was Ca++-dependent at 40 mM K+, and Ca++-independent at K+ concentrations above 40 mM. The dihydropyridine Ca++ channel agonist BAY K 8644 (1 μM) augmented 30 mM K+-evoked release, while the antagonist nifedipine (5 μM) abolished both the BAY K 8644- and K+-enhanced release. Depolarization with the Na+ channel agonist veratridine (50 μM) stimulated taurine efflux, which was completely blocked by pretreatment with tetrodotoxin (2 μM). However, 50 mM K+-evoked taurine release was not affected by tetrodotoxin pretreatment. Substitution of choline Cl for NaCl partially antagonized 50 mM K+-evoked release, and by itself, the Na+ ionophore monensin (50 μM) stimulated release. These results suggest that both K+-evoked and basal taurine release from primary cerebellar neuronal cultures are sensitive to the levels of both intracellular and extracellular Na+ and Ca++ In contrast to previous findings using cerebellar astrocytes, neuronal L-type Ca++ channels, but not voltage-dependent Na+ channels, also appear to be necessary. The implications of these results on taurine's status as a putative neurotransmitter are discussed." @default.
• W2078287186 created "2016-06-24" @default.
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• W2078287186 date "1989-02-01" @default.
• W2078287186 modified "2023-09-23" @default.
• W2078287186 title "Stimulus-coupled taurine efflux from cerebellar neuronal cultures: On the roles of Ca++ and Na+" @default.
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• W2078287186 doi "https://doi.org/10.1002/jnr.490220209" @default.
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