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- W2078288344 abstract "Cross-linking technology combined with tandem mass spectrometry (MS-MS) is a powerful method that provides a rapid solution to the discovery of protein-protein interactions and protein structures. We studied the problem of detecting cross-linked peptides and cross-linked amino acids from tandem mass spectral data. Our method consists of two steps: the first step finds two protein subsequences whose mass sum equals a given mass measured from the mass spectrometry; and the second step finds the best cross-linked amino acids in these two peptide sequences that are optimally correlated to a given tandem mass spectrum. We designed fast and space-efficient algorithms for these two steps, and implemented and tested them on experimental data of cross-linked Hemoglobin proteins." @default.
- W2078288344 created "2016-06-24" @default.
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- W2078288344 date "2001-04-22" @default.
- W2078288344 modified "2023-10-17" @default.
- W2078288344 title "Algorithms for identifying protein cross-links via tandem mass spectrometry" @default.
- W2078288344 cites W2026465178 @default.
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- W2078288344 doi "https://doi.org/10.1145/369133.369177" @default.
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