Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078290018> ?p ?o ?g. }
- W2078290018 endingPage "1367" @default.
- W2078290018 startingPage "1357" @default.
- W2078290018 abstract "Crotoxin is the main neurotoxic component of Crotalus durissus terrificus snake venom and modulates immune and inflammatory responses, interfering with the activity of leukocytes. In the present work, the effects of crotoxin on the number of blood and lymphatic leukocytes and on lymph nodes and spleen lymphocytes population were investigated. The toxin s.c. administered to male Wistar rats, decreases the number of lymphocytes in blood and lymph circulation and increases the content of B and T-lymphocytes in lymph nodes. These effects were detected 1-2h after treatment. The crotoxin molecule is composed of two subunits, an acidic non-toxic polypeptide, named crotapotin and a toxic basic phospholipase A(2) (PLA(2)). PLA(2), but not crotapotin, decreased the number of circulating blood and lymph lymphocytes. Crotoxin promotes leukocyte adherence to endothelial cells of blood microcirculation and to lymph node high endothelial venules, which might contribute to the drop in the number of circulating lymphocytes. Crotoxin increases expression of the adhesion molecule LFA-1 in lymphocytes. The changes in the expression of the adhesion molecule might contribute, at least in part, for the increased leukocyte adhesion to endothelium. Zileuton, a 5-lipoxygenase inhibitor, blocked the decrease in the number of circulating leukocytes induced by crotoxin and also abolished the changes observed in leukocyte-endothelial interactions, suggesting the involvement of lipoxygenase-derived mediators in the effects of the toxin." @default.
- W2078290018 created "2016-06-24" @default.
- W2078290018 creator A5002609438 @default.
- W2078290018 creator A5004080311 @default.
- W2078290018 creator A5006242477 @default.
- W2078290018 creator A5019481173 @default.
- W2078290018 creator A5025336307 @default.
- W2078290018 creator A5027501811 @default.
- W2078290018 creator A5034589912 @default.
- W2078290018 creator A5045714273 @default.
- W2078290018 creator A5055691902 @default.
- W2078290018 creator A5060123744 @default.
- W2078290018 creator A5066256785 @default.
- W2078290018 creator A5078072284 @default.
- W2078290018 creator A5089087117 @default.
- W2078290018 date "2008-06-01" @default.
- W2078290018 modified "2023-10-18" @default.
- W2078290018 title "Crotoxin alters lymphocyte distribution in rats: Involvement of adhesion molecules and lipoxygenase-derived mediators" @default.
- W2078290018 cites W1965316514 @default.
- W2078290018 cites W1965697720 @default.
- W2078290018 cites W1966164413 @default.
- W2078290018 cites W1966684157 @default.
- W2078290018 cites W1967252793 @default.
- W2078290018 cites W1970648150 @default.
- W2078290018 cites W1976005555 @default.
- W2078290018 cites W1980140250 @default.
- W2078290018 cites W1985534693 @default.
- W2078290018 cites W1988338839 @default.
- W2078290018 cites W1988379927 @default.
- W2078290018 cites W1994952794 @default.
- W2078290018 cites W1998542746 @default.
- W2078290018 cites W1999074251 @default.
- W2078290018 cites W2009736986 @default.
- W2078290018 cites W2011746102 @default.
- W2078290018 cites W2012040420 @default.
- W2078290018 cites W2016397584 @default.
- W2078290018 cites W2020958648 @default.
- W2078290018 cites W2021284787 @default.
- W2078290018 cites W2031896438 @default.
- W2078290018 cites W2032494769 @default.
- W2078290018 cites W2034586064 @default.
- W2078290018 cites W2040128874 @default.
- W2078290018 cites W2042626190 @default.
- W2078290018 cites W2047582461 @default.
- W2078290018 cites W2047912256 @default.
- W2078290018 cites W2057338842 @default.
- W2078290018 cites W2062755267 @default.
- W2078290018 cites W2067176005 @default.
- W2078290018 cites W2078252923 @default.
- W2078290018 cites W2084121874 @default.
- W2078290018 cites W2089764248 @default.
- W2078290018 cites W2091902048 @default.
- W2078290018 cites W2098023863 @default.
- W2078290018 cites W2099675490 @default.
- W2078290018 cites W2108813293 @default.
- W2078290018 cites W2110628158 @default.
- W2078290018 cites W2113203684 @default.
- W2078290018 cites W2114369634 @default.
- W2078290018 cites W2116553639 @default.
- W2078290018 cites W2118689280 @default.
- W2078290018 cites W2119388579 @default.
- W2078290018 cites W2126579192 @default.
- W2078290018 cites W2127141798 @default.
- W2078290018 cites W2130284857 @default.
- W2078290018 cites W2132636355 @default.
- W2078290018 cites W2132925738 @default.
- W2078290018 cites W2137583122 @default.
- W2078290018 cites W2139864138 @default.
- W2078290018 cites W2152941397 @default.
- W2078290018 cites W2163360636 @default.
- W2078290018 cites W2186296848 @default.
- W2078290018 cites W2896105429 @default.
- W2078290018 cites W4235059441 @default.
- W2078290018 doi "https://doi.org/10.1016/j.toxicon.2008.03.004" @default.
- W2078290018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18452962" @default.
- W2078290018 hasPublicationYear "2008" @default.
- W2078290018 type Work @default.
- W2078290018 sameAs 2078290018 @default.
- W2078290018 citedByCount "36" @default.
- W2078290018 countsByYear W20782900182012 @default.
- W2078290018 countsByYear W20782900182013 @default.
- W2078290018 countsByYear W20782900182014 @default.
- W2078290018 countsByYear W20782900182015 @default.
- W2078290018 countsByYear W20782900182016 @default.
- W2078290018 countsByYear W20782900182017 @default.
- W2078290018 countsByYear W20782900182018 @default.
- W2078290018 countsByYear W20782900182019 @default.
- W2078290018 countsByYear W20782900182020 @default.
- W2078290018 countsByYear W20782900182021 @default.
- W2078290018 countsByYear W20782900182022 @default.
- W2078290018 countsByYear W20782900182023 @default.
- W2078290018 crossrefType "journal-article" @default.
- W2078290018 hasAuthorship W2078290018A5002609438 @default.
- W2078290018 hasAuthorship W2078290018A5004080311 @default.
- W2078290018 hasAuthorship W2078290018A5006242477 @default.
- W2078290018 hasAuthorship W2078290018A5019481173 @default.
- W2078290018 hasAuthorship W2078290018A5025336307 @default.
- W2078290018 hasAuthorship W2078290018A5027501811 @default.