Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078291088> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2078291088 endingPage "256A" @default.
- W2078291088 startingPage "256A" @default.
- W2078291088 abstract "Cytogenetic techniques have been used to look at structural and functional chromosome abnormalities in leukemic cells. One method, unscheduled DNA synthesis (UDS), which measures DNA repair in non-dividing cells, has been reported to be elevated in peripheral lymphoblasts and fibroblasts from acute myelogenous leukemia patients when exposed in vitro to DNA damaging agents compared to lymphocytes or fibroblasts from normal individuals. We postulated that karyotype abnormalities may correlate with increases in DNA damage and repair. Bone marrow aspirates from 8 children with ALL and 4 children who had aspirates done for reasons other than malignancy were processed for karyotyping. Samples were evaluated for UDS by treatment with hydroxyurea to stop normal DNA synthesis. Tritiated-thymidine was then added for 22 hours. Cells were harvested and prepared for autoradiography. Grain counts per nucleus averaged 0.86±0.09 for ALL samples with abnormal (structurally or numerically) karyotypes (n=4); 0.51±0.13 for ALL samples with normal diploid karyotypes (n=4); and 0.40±0.09 for aspirates from non-leukemic samples with normal karyotypes (n=4). Comparisons of UDS for ALL with abnormal karyotypes to each of the other groups with normal karyotypes was statistically significant (p<0.05). These results suggest that leukemic cells with karyotype abnormalities may have a propensity toward increased DNA breakage and repair." @default.
- W2078291088 created "2016-06-24" @default.
- W2078291088 creator A5018306265 @default.
- W2078291088 creator A5036201918 @default.
- W2078291088 creator A5079175867 @default.
- W2078291088 date "1985-04-01" @default.
- W2078291088 modified "2023-09-26" @default.
- W2078291088 title "871 MEASUREMENT OF DNA BREAKAGE AND REPAIR IN ACUTE LYMPHOCYTIC LEUKEMIA (ALL) CELLS" @default.
- W2078291088 doi "https://doi.org/10.1203/00006450-198504000-00901" @default.
- W2078291088 hasPublicationYear "1985" @default.
- W2078291088 type Work @default.
- W2078291088 sameAs 2078291088 @default.
- W2078291088 citedByCount "0" @default.
- W2078291088 crossrefType "journal-article" @default.
- W2078291088 hasAuthorship W2078291088A5018306265 @default.
- W2078291088 hasAuthorship W2078291088A5036201918 @default.
- W2078291088 hasAuthorship W2078291088A5079175867 @default.
- W2078291088 hasBestOaLocation W20782910881 @default.
- W2078291088 hasConcept C104317684 @default.
- W2078291088 hasConcept C113842279 @default.
- W2078291088 hasConcept C134935766 @default.
- W2078291088 hasConcept C142724271 @default.
- W2078291088 hasConcept C143191323 @default.
- W2078291088 hasConcept C143425029 @default.
- W2078291088 hasConcept C153911025 @default.
- W2078291088 hasConcept C203014093 @default.
- W2078291088 hasConcept C2778461978 @default.
- W2078291088 hasConcept C2780007613 @default.
- W2078291088 hasConcept C2781107101 @default.
- W2078291088 hasConcept C2909962599 @default.
- W2078291088 hasConcept C30481170 @default.
- W2078291088 hasConcept C53226629 @default.
- W2078291088 hasConcept C54355233 @default.
- W2078291088 hasConcept C552990157 @default.
- W2078291088 hasConcept C71924100 @default.
- W2078291088 hasConcept C81885089 @default.
- W2078291088 hasConcept C86803240 @default.
- W2078291088 hasConceptScore W2078291088C104317684 @default.
- W2078291088 hasConceptScore W2078291088C113842279 @default.
- W2078291088 hasConceptScore W2078291088C134935766 @default.
- W2078291088 hasConceptScore W2078291088C142724271 @default.
- W2078291088 hasConceptScore W2078291088C143191323 @default.
- W2078291088 hasConceptScore W2078291088C143425029 @default.
- W2078291088 hasConceptScore W2078291088C153911025 @default.
- W2078291088 hasConceptScore W2078291088C203014093 @default.
- W2078291088 hasConceptScore W2078291088C2778461978 @default.
- W2078291088 hasConceptScore W2078291088C2780007613 @default.
- W2078291088 hasConceptScore W2078291088C2781107101 @default.
- W2078291088 hasConceptScore W2078291088C2909962599 @default.
- W2078291088 hasConceptScore W2078291088C30481170 @default.
- W2078291088 hasConceptScore W2078291088C53226629 @default.
- W2078291088 hasConceptScore W2078291088C54355233 @default.
- W2078291088 hasConceptScore W2078291088C552990157 @default.
- W2078291088 hasConceptScore W2078291088C71924100 @default.
- W2078291088 hasConceptScore W2078291088C81885089 @default.
- W2078291088 hasConceptScore W2078291088C86803240 @default.
- W2078291088 hasIssue "4" @default.
- W2078291088 hasLocation W20782910881 @default.
- W2078291088 hasOpenAccess W2078291088 @default.
- W2078291088 hasPrimaryLocation W20782910881 @default.
- W2078291088 hasRelatedWork W1970446973 @default.
- W2078291088 hasRelatedWork W2003433924 @default.
- W2078291088 hasRelatedWork W2014964654 @default.
- W2078291088 hasRelatedWork W2021486424 @default.
- W2078291088 hasRelatedWork W2056704043 @default.
- W2078291088 hasRelatedWork W2059806707 @default.
- W2078291088 hasRelatedWork W2073588765 @default.
- W2078291088 hasRelatedWork W2166450958 @default.
- W2078291088 hasRelatedWork W2318202140 @default.
- W2078291088 hasRelatedWork W2414312016 @default.
- W2078291088 hasVolume "19" @default.
- W2078291088 isParatext "false" @default.
- W2078291088 isRetracted "false" @default.
- W2078291088 magId "2078291088" @default.
- W2078291088 workType "article" @default.