FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078296703> ?p ?o ?g. }

• W2078296703 endingPage "1638" @default.
• W2078296703 startingPage "1632" @default.
• W2078296703 abstract "Context: Polygonum cuspidatum Sieb. Et Zucc. (Polygonaceae) has been traditionally used in folk medicine to treat various diseases.Objective: This study investigates the ameliorative effects of physcion 8-O-β-glucopyranoside (PSG) isolated from P. cuspidatum on learning and memory in dementia rats induced by Aβ1–40.Materials and methods: Dementia rats were prepared by intracerebroventricular injection of Aβ1–40. PSG (5, 10, 20, and 40 mg/kg/d, for 5 d) was administered orally. Ameliorative activity of PSG in dementia rats was evaluated by the Morris water maze (MWM) test, and its mechanisms were explored by evaluating AchE activity, levels of DA, NE, and 5-HT in hippocampus, and drebrin protein expressions in hippocampus.Results: Our results indicated that PSG (5, 10, 20, and 40 mg/kg/d) significantly inhibited the prolonged latency in dementia rats (p < 0.05), and inhibitory rates were 16.5, 22.7, 33.0, and 44.8% after 5 d of learning, indicating that PSG improves learning and memory of dementia rats. Furthermore, PSG significantly decreased AchE activity (10, 20, and 40 mg/kg/d; p < 0.05), increased 5-HT (20 and 40 mg/kg/d, p < 0.05), NE (10, 20, and 40 mg/kg/d; p < 0.05), and DA levels (5, 10, 20, and 40 mg/kg; p < 0.05) in the hippocampus. Additionally, PSG obviously decreased the Aβ contents in hippocampus (10, 20, and 40 mg/kg/d; p < 0.05), and up-regulated drebrin protein expressions (5, 10, 20, and 40 mg/kg/d; p < 0.05).Conclusions: PSG can significantly enhance learning and memory in Aβ1–40-induced dementia rats, and the mechanisms may be related to increase levels of Ach, 5-HT, NE, and DA, decrease Aβ contents, and up-regulation of drebrin proteins in hippocampus." @default.
• W2078296703 created "2016-06-24" @default.
• W2078296703 creator A5044561307 @default.
• W2078296703 creator A5069101425 @default.
• W2078296703 creator A5075266638 @default.
• W2078296703 creator A5088405482 @default.
• W2078296703 date "2015-05-05" @default.
• W2078296703 modified "2023-09-25" @default.
• W2078296703 title "Ameliorative effects of physcion 8-<i>O</i>-<b>β</b>-glucopyranoside isolated from<i>Polygonum cuspidatum</i>on learning and memory in dementia rats induced by A<b>β</b>_1–40" @default.
• W2078296703 cites W1797218635 @default.
• W2078296703 cites W1971453418 @default.
• W2078296703 cites W1979709728 @default.
• W2078296703 cites W1988868071 @default.
• W2078296703 cites W1991010898 @default.
• W2078296703 cites W1999644296 @default.
• W2078296703 cites W2000252527 @default.
• W2078296703 cites W2012616205 @default.
• W2078296703 cites W2016436495 @default.
• W2078296703 cites W2020984877 @default.
• W2078296703 cites W2024164626 @default.
• W2078296703 cites W2028493381 @default.
• W2078296703 cites W2043640933 @default.
• W2078296703 cites W2044505913 @default.
• W2078296703 cites W2050846196 @default.
• W2078296703 cites W2051314670 @default.
• W2078296703 cites W2056590688 @default.
• W2078296703 cites W2063060972 @default.
• W2078296703 cites W2063072146 @default.
• W2078296703 cites W2066783517 @default.
• W2078296703 cites W2084172837 @default.
• W2078296703 cites W2092489515 @default.
• W2078296703 cites W2093349478 @default.
• W2078296703 cites W2130536213 @default.
• W2078296703 cites W2132349554 @default.
• W2078296703 cites W2320808520 @default.
• W2078296703 cites W4211157318 @default.
• W2078296703 doi "https://doi.org/10.3109/13880209.2014.997251" @default.
• W2078296703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25856718" @default.
• W2078296703 hasPublicationYear "2015" @default.
• W2078296703 type Work @default.
• W2078296703 sameAs 2078296703 @default.
• W2078296703 citedByCount "9" @default.
• W2078296703 countsByYear W20782967032017 @default.
• W2078296703 countsByYear W20782967032019 @default.
• W2078296703 countsByYear W20782967032021 @default.
• W2078296703 countsByYear W20782967032022 @default.
• W2078296703 countsByYear W20782967032023 @default.
• W2078296703 crossrefType "journal-article" @default.
• W2078296703 hasAuthorship W2078296703A5044561307 @default.
• W2078296703 hasAuthorship W2078296703A5069101425 @default.
• W2078296703 hasAuthorship W2078296703A5075266638 @default.
• W2078296703 hasAuthorship W2078296703A5088405482 @default.
• W2078296703 hasConcept C126322002 @default.
• W2078296703 hasConcept C134018914 @default.
• W2078296703 hasConcept C151730666 @default.
• W2078296703 hasConcept C181199279 @default.
• W2078296703 hasConcept C185592680 @default.
• W2078296703 hasConcept C2778816929 @default.
• W2078296703 hasConcept C2779059548 @default.
• W2078296703 hasConcept C2779134260 @default.
• W2078296703 hasConcept C2779343474 @default.
• W2078296703 hasConcept C2779483572 @default.
• W2078296703 hasConcept C2781161787 @default.
• W2078296703 hasConcept C44752575 @default.
• W2078296703 hasConcept C55493867 @default.
• W2078296703 hasConcept C71924100 @default.
• W2078296703 hasConcept C86803240 @default.
• W2078296703 hasConcept C98274493 @default.
• W2078296703 hasConceptScore W2078296703C126322002 @default.
• W2078296703 hasConceptScore W2078296703C134018914 @default.
• W2078296703 hasConceptScore W2078296703C151730666 @default.
• W2078296703 hasConceptScore W2078296703C181199279 @default.
• W2078296703 hasConceptScore W2078296703C185592680 @default.
• W2078296703 hasConceptScore W2078296703C2778816929 @default.
• W2078296703 hasConceptScore W2078296703C2779059548 @default.
• W2078296703 hasConceptScore W2078296703C2779134260 @default.
• W2078296703 hasConceptScore W2078296703C2779343474 @default.
• W2078296703 hasConceptScore W2078296703C2779483572 @default.
• W2078296703 hasConceptScore W2078296703C2781161787 @default.
• W2078296703 hasConceptScore W2078296703C44752575 @default.
• W2078296703 hasConceptScore W2078296703C55493867 @default.
• W2078296703 hasConceptScore W2078296703C71924100 @default.
• W2078296703 hasConceptScore W2078296703C86803240 @default.
• W2078296703 hasConceptScore W2078296703C98274493 @default.
• W2078296703 hasIssue "11" @default.
• W2078296703 hasLocation W20782967031 @default.
• W2078296703 hasLocation W20782967032 @default.
• W2078296703 hasOpenAccess W2078296703 @default.
• W2078296703 hasPrimaryLocation W20782967031 @default.
• W2078296703 hasRelatedWork W1583133707 @default.
• W2078296703 hasRelatedWork W1593625270 @default.
• W2078296703 hasRelatedWork W1978555483 @default.
• W2078296703 hasRelatedWork W2011693499 @default.
• W2078296703 hasRelatedWork W2349076958 @default.
• W2078296703 hasRelatedWork W2355468293 @default.
• W2078296703 hasRelatedWork W2373930340 @default.
• W2078296703 hasRelatedWork W2375813713 @default.
• W2078296703 hasRelatedWork W2376337583 @default.

• next