Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078299250> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2078299250 endingPage "118" @default.
- W2078299250 startingPage "111" @default.
- W2078299250 abstract "The cardiovascular effects of a new antiarrhythmic Class I agent, pirmenol, were assessed noninvasively in 10 patients without heart failure. Infusion of 100 mg pirmenol was given over 30 min following baseline M-mode echocardiography, cuff blood pressure and systolic time interval measurements. The measurements were repeated after the infusion, and 15 and 60 min later. Heart rate increased by 14.7% (P < 0.01). Significant increases were also noted in afterload parameters, mean arterial pressure (+ 10.1%; P < 0.001) and mid-systolic left ventricular wall stress (+ 8.0%; P < 0.05). Concomitantly a slight increase was observed in preload, reflected in lengthening of left ventricular end-diastolic diameter (+ 4.8%; P < 0.05). A decrease in fractional shortening (− 6.5%; P < 0.05) and an increase in pre-ejection period/left ventricular ejection time ratio (+ 16.2%; P < 0.01) suggested a negative inotropic effect. The increased afterload and heart rate may have contributed to changes in these indices, and therefore myocardial depression may appear more pronounced than it actually was. The main effects of intravenous administration of pirmenol are elevations in heart rate and blood pressure. The induced decrease in myocardial contractility is slight." @default.
- W2078299250 created "2016-06-24" @default.
- W2078299250 creator A5018744150 @default.
- W2078299250 creator A5058664894 @default.
- W2078299250 date "1986-02-01" @default.
- W2078299250 modified "2023-10-18" @default.
- W2078299250 title "Hemodynamic effects of pirmenol, a new antiarrhythmic agent, assessed noninvasively" @default.
- W2078299250 cites W1965634011 @default.
- W2078299250 cites W1968402093 @default.
- W2078299250 cites W2000663038 @default.
- W2078299250 cites W2004721942 @default.
- W2078299250 cites W2011419648 @default.
- W2078299250 cites W2014283075 @default.
- W2078299250 cites W2027555503 @default.
- W2078299250 cites W2033498479 @default.
- W2078299250 cites W2036121420 @default.
- W2078299250 cites W2049761029 @default.
- W2078299250 cites W2054343106 @default.
- W2078299250 cites W2064872286 @default.
- W2078299250 cites W2076756839 @default.
- W2078299250 cites W2081635885 @default.
- W2078299250 cites W2092756537 @default.
- W2078299250 cites W2125303743 @default.
- W2078299250 cites W2147732817 @default.
- W2078299250 cites W2151248356 @default.
- W2078299250 cites W2412006949 @default.
- W2078299250 cites W2412200759 @default.
- W2078299250 cites W2415358611 @default.
- W2078299250 cites W2461947942 @default.
- W2078299250 doi "https://doi.org/10.1016/0167-5273(86)90218-4" @default.
- W2078299250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3943931" @default.
- W2078299250 hasPublicationYear "1986" @default.
- W2078299250 type Work @default.
- W2078299250 sameAs 2078299250 @default.
- W2078299250 citedByCount "10" @default.
- W2078299250 crossrefType "journal-article" @default.
- W2078299250 hasAuthorship W2078299250A5018744150 @default.
- W2078299250 hasAuthorship W2078299250A5058664894 @default.
- W2078299250 hasConcept C123576724 @default.
- W2078299250 hasConcept C126322002 @default.
- W2078299250 hasConcept C155710745 @default.
- W2078299250 hasConcept C164705383 @default.
- W2078299250 hasConcept C178853913 @default.
- W2078299250 hasConcept C2777953023 @default.
- W2078299250 hasConcept C39133596 @default.
- W2078299250 hasConcept C42219234 @default.
- W2078299250 hasConcept C48277249 @default.
- W2078299250 hasConcept C57900726 @default.
- W2078299250 hasConcept C71924100 @default.
- W2078299250 hasConcept C84393581 @default.
- W2078299250 hasConceptScore W2078299250C123576724 @default.
- W2078299250 hasConceptScore W2078299250C126322002 @default.
- W2078299250 hasConceptScore W2078299250C155710745 @default.
- W2078299250 hasConceptScore W2078299250C164705383 @default.
- W2078299250 hasConceptScore W2078299250C178853913 @default.
- W2078299250 hasConceptScore W2078299250C2777953023 @default.
- W2078299250 hasConceptScore W2078299250C39133596 @default.
- W2078299250 hasConceptScore W2078299250C42219234 @default.
- W2078299250 hasConceptScore W2078299250C48277249 @default.
- W2078299250 hasConceptScore W2078299250C57900726 @default.
- W2078299250 hasConceptScore W2078299250C71924100 @default.
- W2078299250 hasConceptScore W2078299250C84393581 @default.
- W2078299250 hasIssue "2" @default.
- W2078299250 hasLocation W20782992501 @default.
- W2078299250 hasLocation W20782992502 @default.
- W2078299250 hasOpenAccess W2078299250 @default.
- W2078299250 hasPrimaryLocation W20782992501 @default.
- W2078299250 hasRelatedWork W1995947981 @default.
- W2078299250 hasRelatedWork W2022089943 @default.
- W2078299250 hasRelatedWork W2032964067 @default.
- W2078299250 hasRelatedWork W2044356213 @default.
- W2078299250 hasRelatedWork W2052133574 @default.
- W2078299250 hasRelatedWork W2074671498 @default.
- W2078299250 hasRelatedWork W2087600293 @default.
- W2078299250 hasRelatedWork W2119977103 @default.
- W2078299250 hasRelatedWork W4233501116 @default.
- W2078299250 hasRelatedWork W4235850475 @default.
- W2078299250 hasVolume "10" @default.
- W2078299250 isParatext "false" @default.
- W2078299250 isRetracted "false" @default.
- W2078299250 magId "2078299250" @default.
- W2078299250 workType "article" @default.