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- W2078300888 abstract "Cisplatin is a chemotherapeutic agent for the treatment of various cancers. In this study, cisplatin-induced effects were characterized in vitro model of human liver cells (L02) using 2-DE-based proteomics. Results indicated that different cisplatin treatments primarily induced disturbances in protein synthesis and oxidative stress via differential mechanisms. Since the experimental concentrations of cisplatin described a hormesis effect in cell proliferation of L02 cells, it was expected to reveal the hormesis effects using proteomic markers. However, only confilin-1 was commonly up-regulated in three concentrations of cisplatin treatments showing a hormesis effects with a U-shape regulation. These results were highly consistent with many other toxico-proteomic studies, indicating that the toxico-proteomic responses based on dose-dependent protein responses were incongruent with the theoretically linear or hormetic concentration–effect relationship. Our findings suggested that a macroscopic hormesis phenomenon on the cell proliferation could not be reflected by proteomic responses induced by cisplatin treatments." @default.
- W2078300888 created "2016-06-24" @default.
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- W2078300888 date "2015-01-01" @default.
- W2078300888 modified "2023-10-04" @default.
- W2078300888 title "A 2-DE-based proteomic study on the toxicological effects of cisplatin in L02 cells" @default.
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- W2078300888 doi "https://doi.org/10.1016/j.etap.2014.11.018" @default.
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