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- W2078303230 endingPage "131" @default.
- W2078303230 startingPage "113" @default.
- W2078303230 abstract "Human ovarian cancer is the leading cause of death from gynaecologic malignancy. In most cases, the initial diagnosis is established at an advanced stage, when current therapy can only cure a small proportion of patients. Even in the presence of advanced disease, there is rarely evidence of tumour cells outside the peritoneal cavity (1). Local growth factors may play a part in promoting intraperitoneal spread and growth, and it is conceivable that these could represent unique targets for therapy. Although many studies suggest that malignant ascites may contain one or more specific growth factors required for the proliferation of ovarian cancer cells, so far no specific ascites-borne growth factors have been isolated and identified that are candidates for such a role. A group of bioactive lipids, the lysophosphatidic acids, are present in both serum and in malignant effusions (2). It is possible that the elusive ascitic growth factor may belong to this novel group of established mitogens. The present review summarizes current insights into the function of well-characterized growth factors in ovarian cancer growth, and discusses the potential influence of the above-mentioned ascites-borne lipid growth promoters." @default.
- W2078303230 created "2016-06-24" @default.
- W2078303230 creator A5007237048 @default.
- W2078303230 creator A5061490638 @default.
- W2078303230 creator A5062227574 @default.
- W2078303230 creator A5090670668 @default.
- W2078303230 date "1997-03-01" @default.
- W2078303230 modified "2023-10-10" @default.
- W2078303230 title "Growth factors in human ovarian cancer" @default.
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- W2078303230 doi "https://doi.org/10.1016/s0305-7372(97)90024-4" @default.
- W2078303230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9225962" @default.
- W2078303230 hasPublicationYear "1997" @default.
- W2078303230 type Work @default.