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- W2078303945 endingPage "355" @default.
- W2078303945 startingPage "343" @default.
- W2078303945 abstract "Substance abuse is a common problem among HIV-infected individuals. Importantly, addictions as well as moderate use of alcohol, smoking, or other illicit drugs have been identified as major reasons for non-adherence to antiretroviral therapy (ART) among HIV patients. The literature also suggests a decrease in the response to ART among HIV patients who use these substances, leading to failure to achieve optimal virological response and increased disease progression.This review discusses the challenges with adherence to ART as well as observed drug interactions and known toxicities with major drugs of abuse, such as alcohol, smoking, methamphetamine, cocaine, marijuana, and opioids. The lack of adherence and drug interactions potentially lead to decreased efficacy of ART drugs and increased ART, and drugs of abuse-mediated toxicity. As CYP is the common pathway in metabolizing both ART and drugs of abuse, we discuss the possible involvement of CYP pathways in such drug interactions.We acknowledge that further studies focusing on common metabolic pathways involving CYP and advance research in this area would help to potentially develop novel/alternate interventions and drug dose/regimen adjustments to improve medication outcomes in HIV patients who consume drugs of abuse." @default.
- W2078303945 created "2016-06-24" @default.
- W2078303945 creator A5023688850 @default.
- W2078303945 creator A5048574579 @default.
- W2078303945 creator A5063483613 @default.
- W2078303945 creator A5068270554 @default.
- W2078303945 date "2014-12-24" @default.
- W2078303945 modified "2023-09-25" @default.
- W2078303945 title "Drug–drug interactions between anti-retroviral therapies and drugs of abuse in HIV systems" @default.
- W2078303945 cites W1530988458 @default.
- W2078303945 cites W1876352928 @default.
- W2078303945 cites W1898849923 @default.
- W2078303945 cites W1906150121 @default.
- W2078303945 cites W1963711935 @default.
- W2078303945 cites W1964678251 @default.
- W2078303945 cites W1966716140 @default.
- W2078303945 cites W1967051379 @default.
- W2078303945 cites W1969350793 @default.
- W2078303945 cites W1973677360 @default.
- W2078303945 cites W1974898567 @default.
- W2078303945 cites W1979097034 @default.
- W2078303945 cites W1981159299 @default.
- W2078303945 cites W1983986186 @default.
- W2078303945 cites W1987219223 @default.
- W2078303945 cites W1988367507 @default.
- W2078303945 cites W1991137866 @default.
- W2078303945 cites W1994261721 @default.
- W2078303945 cites W1994338708 @default.
- W2078303945 cites W1995073203 @default.
- W2078303945 cites W1995622516 @default.
- W2078303945 cites W1996646230 @default.
- W2078303945 cites W1997190824 @default.
- W2078303945 cites W1999251932 @default.
- W2078303945 cites W2001555648 @default.
- W2078303945 cites W2002167956 @default.
- W2078303945 cites W2003939878 @default.
- W2078303945 cites W2004650247 @default.
- W2078303945 cites W2013277043 @default.
- W2078303945 cites W2016373232 @default.
- W2078303945 cites W2016821019 @default.
- W2078303945 cites W2019411611 @default.
- W2078303945 cites W2019683429 @default.
- W2078303945 cites W2019939029 @default.
- W2078303945 cites W2021478492 @default.
- W2078303945 cites W2022341367 @default.
- W2078303945 cites W2022523661 @default.
- W2078303945 cites W2022731930 @default.
- W2078303945 cites W2034990918 @default.
- W2078303945 cites W2035415222 @default.
- W2078303945 cites W2037623531 @default.
- W2078303945 cites W2037648424 @default.
- W2078303945 cites W2037870424 @default.
- W2078303945 cites W2041080087 @default.
- W2078303945 cites W2043249607 @default.
- W2078303945 cites W2050248755 @default.
- W2078303945 cites W2052919320 @default.
- W2078303945 cites W2052940672 @default.
- W2078303945 cites W2053083201 @default.
- W2078303945 cites W2053091454 @default.
- W2078303945 cites W2056261079 @default.
- W2078303945 cites W2058575099 @default.
- W2078303945 cites W2059120904 @default.
- W2078303945 cites W2060032113 @default.
- W2078303945 cites W2060642037 @default.
- W2078303945 cites W2060733040 @default.
- W2078303945 cites W2064961024 @default.
- W2078303945 cites W2065780093 @default.
- W2078303945 cites W2066413409 @default.
- W2078303945 cites W2067428200 @default.
- W2078303945 cites W2074578424 @default.
- W2078303945 cites W2075571365 @default.
- W2078303945 cites W2076161782 @default.
- W2078303945 cites W2078470317 @default.
- W2078303945 cites W2078785649 @default.
- W2078303945 cites W2078898097 @default.
- W2078303945 cites W2079088593 @default.
- W2078303945 cites W2081298828 @default.
- W2078303945 cites W2082783124 @default.
- W2078303945 cites W2083131011 @default.
- W2078303945 cites W2083135851 @default.
- W2078303945 cites W2083419315 @default.
- W2078303945 cites W2086445143 @default.
- W2078303945 cites W2088525760 @default.
- W2078303945 cites W2089214576 @default.
- W2078303945 cites W2089374096 @default.
- W2078303945 cites W2090772210 @default.
- W2078303945 cites W2091033938 @default.
- W2078303945 cites W2092825895 @default.
- W2078303945 cites W2094984524 @default.
- W2078303945 cites W2096523918 @default.
- W2078303945 cites W2102073909 @default.
- W2078303945 cites W2102698621 @default.
- W2078303945 cites W2107239289 @default.
- W2078303945 cites W2107897538 @default.
- W2078303945 cites W2111087316 @default.
- W2078303945 cites W2115322174 @default.
- W2078303945 cites W2117802425 @default.
- W2078303945 cites W2118370392 @default.