FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078307923> ?p ?o ?g. }

• W2078307923 endingPage "832" @default.
• W2078307923 startingPage "817" @default.
• W2078307923 abstract "The hypothesis was tested that bovine preantral follicles can be stimulated to grow in vitro by FSH and by the mitogens, epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), but not by transforming growth factor-β (TGFβ), which generally inhibits EGF and bFGF action. Preantral follicles, 60 to 179 μm in diameter, were isolated from fetal ovaries by treatment with collagenase and DNase and cultured for 6 d in serum-free medium, with or without FSH and growth factors. Basic FGF (50 ng/ml), and to a lesser extent FSH (100 ng/ml) and EGF (50 ng/ml), stimulated thymidine incorporation by granulosa cells in bovine preantral follicles compared to control cultures (8-, 4- and 2.5-fold the labeling index of the controls; P < 0.05). Alone TGFβ (10 ng/ml) had no effect on 3H-thymidine incorporation, but it completely inhibited the bFGF- but not the FSH-stimulated increase in the labeling index and mean follicular diameter of preantral follicles (P < 0.05). By the end of the culture period oocytes in most treatments had degenerated, and the few surviving oocytes were in preantral follicles cultured with FSH or bFGF. Progesterone accumulation was greater (P < 0.05) in the presence of FSH (100 ng/ml) or EGF (50 ng/ml) than with bFGF, TGFβ or control medium. Basic FGF strongly inhibited the effect of FSH on progesterone secretion (P < 0.05). Only FSH stimulated the conversion of exogenous testosterone to estradiol and both bFGF and TGFβ markedly inhibited FSH-stimulated estradiol accumulation. These results indicate that proliferation of granulosa cells of bovine preantral follicles can be stimulated by bFGF, FSH and EGF, whereas TGFβ inhibits growth, and that they are steroidogenically active in culture. Basic FGF and TGFβ antagonize FSH-stimulated steroid production by granulosa cells of cultured bovine preantral follicles." @default.
• W2078307923 created "2016-06-24" @default.
• W2078307923 creator A5033394904 @default.
• W2078307923 creator A5041744744 @default.
• W2078307923 creator A5077895064 @default.
• W2078307923 date "1996-03-01" @default.
• W2078307923 modified "2023-09-27" @default.
• W2078307923 title "FSH and growth factors affect the growth and endocrine function in vitro of granulosa cells of bovine preantral follicles" @default.
• W2078307923 cites W1534163224 @default.
• W2078307923 cites W1554960389 @default.
• W2078307923 cites W1593287105 @default.
• W2078307923 cites W1966240221 @default.
• W2078307923 cites W1973983380 @default.
• W2078307923 cites W1992078851 @default.
• W2078307923 cites W1992915766 @default.
• W2078307923 cites W1996315568 @default.
• W2078307923 cites W1997241192 @default.
• W2078307923 cites W2006192685 @default.
• W2078307923 cites W2007768242 @default.
• W2078307923 cites W2010833294 @default.
• W2078307923 cites W2011253631 @default.
• W2078307923 cites W2011348946 @default.
• W2078307923 cites W2021283573 @default.
• W2078307923 cites W2027745473 @default.
• W2078307923 cites W2035048391 @default.
• W2078307923 cites W2037812119 @default.
• W2078307923 cites W2042861570 @default.
• W2078307923 cites W2048785122 @default.
• W2078307923 cites W2048989707 @default.
• W2078307923 cites W2052651446 @default.
• W2078307923 cites W2058265314 @default.
• W2078307923 cites W2060572191 @default.
• W2078307923 cites W2062953809 @default.
• W2078307923 cites W2064982147 @default.
• W2078307923 cites W2065437151 @default.
• W2078307923 cites W2065460036 @default.
• W2078307923 cites W2067867779 @default.
• W2078307923 cites W2075086587 @default.
• W2078307923 cites W2075242594 @default.
• W2078307923 cites W2079251901 @default.
• W2078307923 cites W2087774836 @default.
• W2078307923 cites W2090136483 @default.
• W2078307923 cites W2103834864 @default.
• W2078307923 cites W2117206996 @default.
• W2078307923 cites W2121181951 @default.
• W2078307923 cites W2131391777 @default.
• W2078307923 cites W2142885851 @default.
• W2078307923 cites W2160972227 @default.
• W2078307923 cites W4295554713 @default.
• W2078307923 doi "https://doi.org/10.1016/0093-691x(96)00011-8" @default.
• W2078307923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16727844" @default.
• W2078307923 hasPublicationYear "1996" @default.
• W2078307923 type Work @default.
• W2078307923 sameAs 2078307923 @default.
• W2078307923 citedByCount "152" @default.
• W2078307923 countsByYear W20783079232012 @default.
• W2078307923 countsByYear W20783079232013 @default.
• W2078307923 countsByYear W20783079232014 @default.
• W2078307923 countsByYear W20783079232015 @default.
• W2078307923 countsByYear W20783079232016 @default.
• W2078307923 countsByYear W20783079232017 @default.
• W2078307923 countsByYear W20783079232018 @default.
• W2078307923 countsByYear W20783079232019 @default.
• W2078307923 countsByYear W20783079232020 @default.
• W2078307923 countsByYear W20783079232021 @default.
• W2078307923 countsByYear W20783079232022 @default.
• W2078307923 countsByYear W20783079232023 @default.
• W2078307923 crossrefType "journal-article" @default.
• W2078307923 hasAuthorship W2078307923A5033394904 @default.
• W2078307923 hasAuthorship W2078307923A5041744744 @default.
• W2078307923 hasAuthorship W2078307923A5077895064 @default.
• W2078307923 hasBestOaLocation W20783079231 @default.
• W2078307923 hasConcept C126322002 @default.
• W2078307923 hasConcept C134018914 @default.
• W2078307923 hasConcept C170493617 @default.
• W2078307923 hasConcept C181199279 @default.
• W2078307923 hasConcept C185592680 @default.
• W2078307923 hasConcept C187785154 @default.
• W2078307923 hasConcept C202751555 @default.
• W2078307923 hasConcept C2775960820 @default.
• W2078307923 hasConcept C2776362946 @default.
• W2078307923 hasConcept C2777108182 @default.
• W2078307923 hasConcept C2777203538 @default.
• W2078307923 hasConcept C2777587049 @default.
• W2078307923 hasConcept C2778394429 @default.
• W2078307923 hasConcept C2778575703 @default.
• W2078307923 hasConcept C2779279165 @default.
• W2078307923 hasConcept C2779404806 @default.
• W2078307923 hasConcept C55493867 @default.
• W2078307923 hasConcept C71315377 @default.
• W2078307923 hasConcept C71924100 @default.
• W2078307923 hasConcept C74373430 @default.
• W2078307923 hasConcept C86803240 @default.
• W2078307923 hasConceptScore W2078307923C126322002 @default.
• W2078307923 hasConceptScore W2078307923C134018914 @default.
• W2078307923 hasConceptScore W2078307923C170493617 @default.
• W2078307923 hasConceptScore W2078307923C181199279 @default.
• W2078307923 hasConceptScore W2078307923C185592680 @default.

• next