FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078308152> ?p ?o ?g. }

• W2078308152 endingPage "1084" @default.
• W2078308152 startingPage "1075" @default.
• W2078308152 abstract "The goal of this study was to develop a novel oil-body nanoemulsion (ONE) for Ginkgolide B (GB) and to conduct pharmacokinetics and pharmacodynamics evaluations. GB-ONE was prepared by O/O emulsion method. The differences in pharmacokinetics parameters and tissue distribution of rats after oral administrated with GB-ONE were investigated by liquid chromatography-tandem mass spectrometry. Changes in the ethological and pathological characterizations of the Alzheimer's disease rats after treated with GB-ONE were evaluated by Morris water maze (MWM) and pathological section, respectively. Furthermore, choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) activity in hippocampus was analyzed by spectrophotometric method. The results indicated that the AUC of GB in rats' plasma was significantly improved after incorporated into ONE, and GB-ONE was significantly targeted into brain. In MWM experiment, memory improvement of rats with cognition impaired was confirmed after administrated with GB-ONE. Furthermore, GB-ONE significantly inhibited AchE activity and enhanced the activity of ChAT in the hippocampus. The overall results implicated that the novel ONE was effective for improving the drawbacks of GB and showed great potential for clinical application." @default.
• W2078308152 created "2016-06-24" @default.
• W2078308152 creator A5011041194 @default.
• W2078308152 creator A5019095655 @default.
• W2078308152 creator A5024584263 @default.
• W2078308152 creator A5036129307 @default.
• W2078308152 creator A5088893498 @default.
• W2078308152 date "2014-04-01" @default.
• W2078308152 modified "2023-10-01" @default.
• W2078308152 title "A Novel Oil-Body Nanoemulsion Formulation of Ginkgolide B: Pharmacokinetics Study and In Vivo Pharmacodynamics Evaluations" @default.
• W2078308152 cites W1484197568 @default.
• W2078308152 cites W1969096958 @default.
• W2078308152 cites W1989123508 @default.
• W2078308152 cites W2004092919 @default.
• W2078308152 cites W2009489099 @default.
• W2078308152 cites W2034242899 @default.
• W2078308152 cites W2036999005 @default.
• W2078308152 cites W2051314670 @default.
• W2078308152 cites W2068091371 @default.
• W2078308152 cites W2071905391 @default.
• W2078308152 cites W2083627546 @default.
• W2078308152 cites W2090194652 @default.
• W2078308152 cites W2099637886 @default.
• W2078308152 cites W2104893271 @default.
• W2078308152 cites W2107806146 @default.
• W2078308152 cites W2112689297 @default.
• W2078308152 cites W2159392324 @default.
• W2078308152 cites W2393548488 @default.
• W2078308152 doi "https://doi.org/10.1002/jps.23866" @default.
• W2078308152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24496859" @default.
• W2078308152 hasPublicationYear "2014" @default.
• W2078308152 type Work @default.
• W2078308152 sameAs 2078308152 @default.
• W2078308152 citedByCount "15" @default.
• W2078308152 countsByYear W20783081522013 @default.
• W2078308152 countsByYear W20783081522015 @default.
• W2078308152 countsByYear W20783081522016 @default.
• W2078308152 countsByYear W20783081522018 @default.
• W2078308152 countsByYear W20783081522019 @default.
• W2078308152 countsByYear W20783081522020 @default.
• W2078308152 countsByYear W20783081522021 @default.
• W2078308152 countsByYear W20783081522022 @default.
• W2078308152 countsByYear W20783081522023 @default.
• W2078308152 crossrefType "journal-article" @default.
• W2078308152 hasAuthorship W2078308152A5011041194 @default.
• W2078308152 hasAuthorship W2078308152A5019095655 @default.
• W2078308152 hasAuthorship W2078308152A5024584263 @default.
• W2078308152 hasAuthorship W2078308152A5036129307 @default.
• W2078308152 hasAuthorship W2078308152A5088893498 @default.
• W2078308152 hasConcept C111113717 @default.
• W2078308152 hasConcept C112705442 @default.
• W2078308152 hasConcept C126322002 @default.
• W2078308152 hasConcept C150903083 @default.
• W2078308152 hasConcept C181199279 @default.
• W2078308152 hasConcept C185592680 @default.
• W2078308152 hasConcept C198399640 @default.
• W2078308152 hasConcept C207001950 @default.
• W2078308152 hasConcept C2775910092 @default.
• W2078308152 hasConcept C2778816929 @default.
• W2078308152 hasConcept C2779059548 @default.
• W2078308152 hasConcept C2781161787 @default.
• W2078308152 hasConcept C44752575 @default.
• W2078308152 hasConcept C55493867 @default.
• W2078308152 hasConcept C71924100 @default.
• W2078308152 hasConcept C86803240 @default.
• W2078308152 hasConcept C98274493 @default.
• W2078308152 hasConceptScore W2078308152C111113717 @default.
• W2078308152 hasConceptScore W2078308152C112705442 @default.
• W2078308152 hasConceptScore W2078308152C126322002 @default.
• W2078308152 hasConceptScore W2078308152C150903083 @default.
• W2078308152 hasConceptScore W2078308152C181199279 @default.
• W2078308152 hasConceptScore W2078308152C185592680 @default.
• W2078308152 hasConceptScore W2078308152C198399640 @default.
• W2078308152 hasConceptScore W2078308152C207001950 @default.
• W2078308152 hasConceptScore W2078308152C2775910092 @default.
• W2078308152 hasConceptScore W2078308152C2778816929 @default.
• W2078308152 hasConceptScore W2078308152C2779059548 @default.
• W2078308152 hasConceptScore W2078308152C2781161787 @default.
• W2078308152 hasConceptScore W2078308152C44752575 @default.
• W2078308152 hasConceptScore W2078308152C55493867 @default.
• W2078308152 hasConceptScore W2078308152C71924100 @default.
• W2078308152 hasConceptScore W2078308152C86803240 @default.
• W2078308152 hasConceptScore W2078308152C98274493 @default.
• W2078308152 hasIssue "4" @default.
• W2078308152 hasLocation W20783081521 @default.
• W2078308152 hasLocation W20783081522 @default.
• W2078308152 hasOpenAccess W2078308152 @default.
• W2078308152 hasPrimaryLocation W20783081521 @default.
• W2078308152 hasRelatedWork W1593625270 @default.
• W2078308152 hasRelatedWork W1998587742 @default.
• W2078308152 hasRelatedWork W2078308152 @default.
• W2078308152 hasRelatedWork W2094009143 @default.
• W2078308152 hasRelatedWork W2186048183 @default.
• W2078308152 hasRelatedWork W2358863768 @default.
• W2078308152 hasRelatedWork W2370439329 @default.
• W2078308152 hasRelatedWork W2376337583 @default.
• W2078308152 hasRelatedWork W2376918810 @default.
• W2078308152 hasRelatedWork W2397058095 @default.

• next