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- W2078309167 abstract "The binding of the clinically inactive benzodiazepine [3H]RO-5-4864 to brain membranes was investigated. The peripheral type benzodiazepine binding site was demonstrated in brain with an apparent Kd of 1.6 nM and a Bmax of 20 fmol/mg protein. Monophasic Scatchard plots indicate a homogenous population of a high affinity sites. The major inhibitory transmitter GABA, has no effect on [3H]RO-5-4864 binding to extensively wash brain membranes. The peripheral type benzodiazepine binding site found in brain is therefore not modulated GABA." @default.
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- W2078309167 title "Differential effects of GABA on peripheral and central type benzodiazepine binding sites in brain" @default.
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- W2078309167 doi "https://doi.org/10.1016/0304-3940(82)90289-0" @default.
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