Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078311356> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2078311356 endingPage "325" @default.
- W2078311356 startingPage "311" @default.
- W2078311356 abstract "The complement system of the cobra snake is of particular interest because cobra venom contains cobra venom factor (CVF), a protein that is related to C3 and forms a stable C3 convertase with mammalian Factor B. We investigated the alternative pathway of cobra complement. Cobra plasma lysed erythrocytes in presence of Mg-EGTA of some mammalian species, but not cobra erythrocytes. The hemolytic activity was inhibited by EDTA and destroyed by heating. Preincubation of cobra plasma with alternative pathway activators (zymosan, inulin, lipopolysaccharide), with small nucleophiles (methylamine, hydrazine), or with chaotropes (KSCN) abrogated the hemolytic activity. The activity of cobra plasma was not affected by CVF. Cobra plasma also lysed EAC1423 cells in presence of EDTA but not EAC142 cells (prepared with sheep erythrocytes, rabbit antibody, and human complement proteins) indicating the presence of C5 in cobra plasma that is susceptible to activation by the human C5 convertase. These results indicate that the cobra has a complement system with an alternative pathway very similar to mammalian complement." @default.
- W2078311356 created "2016-06-24" @default.
- W2078311356 creator A5005122560 @default.
- W2078311356 creator A5073239787 @default.
- W2078311356 date "1985-03-01" @default.
- W2078311356 modified "2023-09-23" @default.
- W2078311356 title "The cobra complement system: I. The alternative pathway of activation" @default.
- W2078311356 cites W1491564174 @default.
- W2078311356 cites W1497166035 @default.
- W2078311356 cites W1502671196 @default.
- W2078311356 cites W1582099101 @default.
- W2078311356 cites W1853641470 @default.
- W2078311356 cites W1987226162 @default.
- W2078311356 cites W1995640513 @default.
- W2078311356 cites W2010077713 @default.
- W2078311356 cites W2011313125 @default.
- W2078311356 cites W2014193581 @default.
- W2078311356 cites W2019701223 @default.
- W2078311356 cites W2019816897 @default.
- W2078311356 cites W2038951335 @default.
- W2078311356 cites W2040026760 @default.
- W2078311356 cites W2047809554 @default.
- W2078311356 cites W2077110004 @default.
- W2078311356 cites W2097222143 @default.
- W2078311356 cites W2099607632 @default.
- W2078311356 cites W2135324460 @default.
- W2078311356 cites W2166320123 @default.
- W2078311356 cites W2179044022 @default.
- W2078311356 cites W2273521055 @default.
- W2078311356 cites W2312921356 @default.
- W2078311356 cites W2321291970 @default.
- W2078311356 doi "https://doi.org/10.1016/0145-305x(85)90122-3" @default.
- W2078311356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3894085" @default.
- W2078311356 hasPublicationYear "1985" @default.
- W2078311356 type Work @default.
- W2078311356 sameAs 2078311356 @default.
- W2078311356 citedByCount "28" @default.
- W2078311356 countsByYear W20783113562015 @default.
- W2078311356 countsByYear W20783113562016 @default.
- W2078311356 countsByYear W20783113562017 @default.
- W2078311356 countsByYear W20783113562018 @default.
- W2078311356 countsByYear W20783113562020 @default.
- W2078311356 countsByYear W20783113562021 @default.
- W2078311356 countsByYear W20783113562023 @default.
- W2078311356 crossrefType "journal-article" @default.
- W2078311356 hasAuthorship W2078311356A5005122560 @default.
- W2078311356 hasAuthorship W2078311356A5073239787 @default.
- W2078311356 hasConcept C111684460 @default.
- W2078311356 hasConcept C153911025 @default.
- W2078311356 hasConcept C159654299 @default.
- W2078311356 hasConcept C171279029 @default.
- W2078311356 hasConcept C182629451 @default.
- W2078311356 hasConcept C189446657 @default.
- W2078311356 hasConcept C199360897 @default.
- W2078311356 hasConcept C202751555 @default.
- W2078311356 hasConcept C203014093 @default.
- W2078311356 hasConcept C2778870864 @default.
- W2078311356 hasConcept C2779547071 @default.
- W2078311356 hasConcept C41008148 @default.
- W2078311356 hasConcept C55493867 @default.
- W2078311356 hasConcept C86803240 @default.
- W2078311356 hasConcept C9478725 @default.
- W2078311356 hasConceptScore W2078311356C111684460 @default.
- W2078311356 hasConceptScore W2078311356C153911025 @default.
- W2078311356 hasConceptScore W2078311356C159654299 @default.
- W2078311356 hasConceptScore W2078311356C171279029 @default.
- W2078311356 hasConceptScore W2078311356C182629451 @default.
- W2078311356 hasConceptScore W2078311356C189446657 @default.
- W2078311356 hasConceptScore W2078311356C199360897 @default.
- W2078311356 hasConceptScore W2078311356C202751555 @default.
- W2078311356 hasConceptScore W2078311356C203014093 @default.
- W2078311356 hasConceptScore W2078311356C2778870864 @default.
- W2078311356 hasConceptScore W2078311356C2779547071 @default.
- W2078311356 hasConceptScore W2078311356C41008148 @default.
- W2078311356 hasConceptScore W2078311356C55493867 @default.
- W2078311356 hasConceptScore W2078311356C86803240 @default.
- W2078311356 hasConceptScore W2078311356C9478725 @default.
- W2078311356 hasIssue "2" @default.
- W2078311356 hasLocation W20783113561 @default.
- W2078311356 hasLocation W20783113562 @default.
- W2078311356 hasOpenAccess W2078311356 @default.
- W2078311356 hasPrimaryLocation W20783113561 @default.
- W2078311356 hasRelatedWork W13594097 @default.
- W2078311356 hasRelatedWork W1538060285 @default.
- W2078311356 hasRelatedWork W1573693344 @default.
- W2078311356 hasRelatedWork W2047255720 @default.
- W2078311356 hasRelatedWork W2070348590 @default.
- W2078311356 hasRelatedWork W2078311356 @default.
- W2078311356 hasRelatedWork W2280112324 @default.
- W2078311356 hasRelatedWork W2415562614 @default.
- W2078311356 hasRelatedWork W2462315822 @default.
- W2078311356 hasRelatedWork W4313341453 @default.
- W2078311356 hasVolume "9" @default.
- W2078311356 isParatext "false" @default.
- W2078311356 isRetracted "false" @default.
- W2078311356 magId "2078311356" @default.
- W2078311356 workType "article" @default.