Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078311939> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2078311939 abstract "Mismatched double-stranded RNA of the form r(I)n.r(C12-U)n (Ampligen) has been shown to be active against human immunodeficiency virus type 1 (HIV-1) using CEM and C3 cells as targets for infection by the highly similar HIV-1 isolates HTLV-IIIB and LAV (Montefiori, D.C. and Mitchell, W.M., 1987, Proc. Natl. Acad. Sci. U.S.A., 84, 2985-2989). The scope of Ampligen's anti-HIV-1 activity was examined in this study using the genetically divergent HIV-1 isolate HTLV-IIIRF, two additional target T-cell lines, H9 and MT-2, and a monocyte/macrophage cell line, U937. As judged by indirect immunofluorescence, reverse transcriptase activity and vital dye uptake, Ampligen was active against HTLV-IIIRF in H9, MT-2, C3 and U937 cells in addition to being active against HTLV-IIIB in U937 cells. A minimum of 1 h preincubation of cells (MT-2) with Ampligen was required for maximum activity. These results suggest that Ampligen's potential clinical efficacy may not be limited by either the highly variable nature or host cell range of HIV-1." @default.
- W2078311939 created "2016-06-24" @default.
- W2078311939 creator A5004036928 @default.
- W2078311939 creator A5052459029 @default.
- W2078311939 creator A5085333102 @default.
- W2078311939 date "1988-01-01" @default.
- W2078311939 modified "2023-09-27" @default.
- W2078311939 title "Mismatched dsRNA (Ampligen) induces protection against genomic variants of the human immunodeffciency virus type 1 (HIV-1) in a multiplicity of target cells" @default.
- W2078311939 cites W1608628964 @default.
- W2078311939 cites W1778074134 @default.
- W2078311939 cites W1971236744 @default.
- W2078311939 cites W1977808193 @default.
- W2078311939 cites W1991670386 @default.
- W2078311939 cites W2007879674 @default.
- W2078311939 cites W2015326137 @default.
- W2078311939 cites W2020663733 @default.
- W2078311939 cites W2030692398 @default.
- W2078311939 cites W2032790020 @default.
- W2078311939 cites W2060641378 @default.
- W2078311939 cites W2074194642 @default.
- W2078311939 cites W2112834292 @default.
- W2078311939 cites W2114717159 @default.
- W2078311939 cites W2133764756 @default.
- W2078311939 cites W2137267461 @default.
- W2078311939 cites W2167286967 @default.
- W2078311939 doi "https://doi.org/10.1016/0166-3542(88)90066-6" @default.
- W2078311939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2968777" @default.
- W2078311939 hasPublicationYear "1988" @default.
- W2078311939 type Work @default.
- W2078311939 sameAs 2078311939 @default.
- W2078311939 citedByCount "10" @default.
- W2078311939 countsByYear W20783119392012 @default.
- W2078311939 countsByYear W20783119392014 @default.
- W2078311939 countsByYear W20783119392018 @default.
- W2078311939 crossrefType "journal-article" @default.
- W2078311939 hasAuthorship W2078311939A5004036928 @default.
- W2078311939 hasAuthorship W2078311939A5052459029 @default.
- W2078311939 hasAuthorship W2078311939A5085333102 @default.
- W2078311939 hasConcept C104317684 @default.
- W2078311939 hasConcept C108634530 @default.
- W2078311939 hasConcept C153911025 @default.
- W2078311939 hasConcept C156719811 @default.
- W2078311939 hasConcept C159047783 @default.
- W2078311939 hasConcept C159654299 @default.
- W2078311939 hasConcept C185592680 @default.
- W2078311939 hasConcept C202751555 @default.
- W2078311939 hasConcept C203233990 @default.
- W2078311939 hasConcept C2522874641 @default.
- W2078311939 hasConcept C2778236600 @default.
- W2078311939 hasConcept C2779244956 @default.
- W2078311939 hasConcept C54355233 @default.
- W2078311939 hasConcept C67705224 @default.
- W2078311939 hasConcept C81885089 @default.
- W2078311939 hasConcept C86803240 @default.
- W2078311939 hasConceptScore W2078311939C104317684 @default.
- W2078311939 hasConceptScore W2078311939C108634530 @default.
- W2078311939 hasConceptScore W2078311939C153911025 @default.
- W2078311939 hasConceptScore W2078311939C156719811 @default.
- W2078311939 hasConceptScore W2078311939C159047783 @default.
- W2078311939 hasConceptScore W2078311939C159654299 @default.
- W2078311939 hasConceptScore W2078311939C185592680 @default.
- W2078311939 hasConceptScore W2078311939C202751555 @default.
- W2078311939 hasConceptScore W2078311939C203233990 @default.
- W2078311939 hasConceptScore W2078311939C2522874641 @default.
- W2078311939 hasConceptScore W2078311939C2778236600 @default.
- W2078311939 hasConceptScore W2078311939C2779244956 @default.
- W2078311939 hasConceptScore W2078311939C54355233 @default.
- W2078311939 hasConceptScore W2078311939C67705224 @default.
- W2078311939 hasConceptScore W2078311939C81885089 @default.
- W2078311939 hasConceptScore W2078311939C86803240 @default.
- W2078311939 hasLocation W20783119391 @default.
- W2078311939 hasLocation W20783119392 @default.
- W2078311939 hasOpenAccess W2078311939 @default.
- W2078311939 hasPrimaryLocation W20783119391 @default.
- W2078311939 hasRelatedWork W1487857142 @default.
- W2078311939 hasRelatedWork W1979841434 @default.
- W2078311939 hasRelatedWork W2005562014 @default.
- W2078311939 hasRelatedWork W2077627309 @default.
- W2078311939 hasRelatedWork W2078311939 @default.
- W2078311939 hasRelatedWork W2116464980 @default.
- W2078311939 hasRelatedWork W2161017057 @default.
- W2078311939 hasRelatedWork W2188973184 @default.
- W2078311939 hasRelatedWork W2467445536 @default.
- W2078311939 hasRelatedWork W2522030167 @default.
- W2078311939 isParatext "false" @default.
- W2078311939 isRetracted "false" @default.
- W2078311939 magId "2078311939" @default.
- W2078311939 workType "article" @default.