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- W2078311949 abstract "Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor. Recent evidence suggests that environmental influences on the brain and behavior may be transmitted from one generation to the next. We used a prenatal nicotine exposure (PNE) mouse model of ADHD to test the hypothesis that PNE-induced hyperactivity, a proxy for human ADHD phenotype, is transmitted from one generation to the next. Our data reveal transgenerational transmission of PNE-induced hyperactivity in mice via the maternal but not the paternal line of descent. We suggest that transgenerational transmission is a plausible mechanism for propagation of environmentally induced ADHD phenotypes in the population." @default.
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- W2078311949 date "2014-02-19" @default.
- W2078311949 modified "2023-10-11" @default.
- W2078311949 title "Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD" @default.
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- W2078311949 doi "https://doi.org/10.1523/jneurosci.4402-13.2014" @default.
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