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- W2078312254 abstract "To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17β-estradiol dose dependently inhibited gene expression and peptide secretion of ET-1. This inhibitory effect of 17β-estradiol was more marked when ET-1 production was stimulated by transforming growth factor-β1. Simultaneous addition of ICI 182,780, a pure estrogen receptor antagonist, completely blocked the effect of 17β-estradiol, indicating that 17β-estradiol acted via estrogen receptor. These results suggest that reduced ET-1 production by endothelial cells may be involved in the vasoprotective effect of estrogen." @default.
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- W2078312254 date "1998-10-01" @default.
- W2078312254 modified "2023-09-30" @default.
- W2078312254 title "Estrogen Attenuates Endothelin-1 Production by Bovine Endothelial Cells via Estrogen Receptor" @default.
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- W2078312254 doi "https://doi.org/10.1006/bbrc.1998.9409" @default.
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