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- W2078312651 abstract "Les traitements conventionnels de l’asthme (corticostéroïdes et bronchodilatateurs) permettent aujourd’hui de contrôler les symptômes chez la très grande majorité des patients. La prise en charge reste malgré tout difficile chez certains. La compréhension des mécanismes moléculaires de l’inflammation asthmatique a permis l’identification de nouvelles cibles thérapeutiques : lymphocytes et cytokines Th2 (interleukine-4, interleukine-5), cytokines et chimiokines proéosinophiles, et cellules effectrices au premier rang desquelles, le polynucléaire éosinophile. De nouvelles stratégies sont maintenant développées pour inhiber le rôle des polynucléaires éosinophiles dans la maladie asthmatique. Les modèles animaux sont séduisants et permettent l’évaluation de ces nouveaux traitements, mais il reste maintenant à établir leur pertinence chez l’homme. Bronchial asthma is a common disease, of which most of patients are adequately treated by standard therapy. However, a small group of patients with asthma has severe disease that cannot be controlled by conventional strategies (Inhaled corticosteroids and bronchodilatator). The central role of Th2 lymphocytes and cytokines (Interleukin-4, interleukin-5), as well as eosinophils has been highlighted in asthmatics individuals. Eosinophils are generally regarded as a particularly harmful element in the asthmatic airways, and chemokines and proeosinophilic cytokines may play a central role in this condition. Several novel strategies have now been tested in animal models of asthma including inhibitors of proeosinophilic cytokines. The challenge, now, is to establish their therapeutic interest in human asthma." @default.
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- W2078312651 date "2002-04-01" @default.
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- W2078312651 title "L’éosinophile, une cible pour les thérapeutiques du futur" @default.
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