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• W2078313885 endingPage "170" @default.
• W2078313885 startingPage "162" @default.
• W2078313885 abstract "The corticotropin releasing hormone receptors (CRHR) and the arthropod diuretic hormone 44 receptors (DH44R) are structurally and functionally related members of the G protein-coupled receptors (GPCR) of the secretin-like receptor superfamily. We show here that they derive from a bilaterian predecessor. In protostomes, the receptor became DH44R that has been identified and functionally characterised in several arthropods but the gene seems to be absent from nematode genomes. Duplicate DH44R genes (DH44 R1 and DH44R2) have been described in some arthropods resulting from lineage-specific duplications. Recently, CRHR-DH44R-like receptors have been identified in the genomes of some lophotrochozoans (molluscs, which have a lineage-specific gene duplication, and annelids) as well as representatives of early diverging deuterostomes. Vertebrates have previously been reported to have two CRHR receptors that were named CRHR1 and CRHR2. To resolve their origin we have analysed recently assembled genomes from representatives of early vertebrate divergencies including elephant shark, spotted gar and coelacanth. We show here by analysis of synteny conservation that the two CRHR genes arose from a common ancestral gene in the early vertebrate tetraploidizations (2R) approximately 500 million years ago. Subsequently, the teleost-specific tetraploidization (3R) resulted in a duplicate of CRHR1 that has been lost in some teleost lineages. These results help distinguish orthology and paralogy relationships and will allow studies of functional conservation and changes during evolution of the individual members of the receptor family and their multiple native peptide agonists." @default.
• W2078313885 created "2016-06-24" @default.
• W2078313885 creator A5004982383 @default.
• W2078313885 creator A5048552837 @default.
• W2078313885 creator A5061245649 @default.
• W2078313885 creator A5085600803 @default.
• W2078313885 date "2014-12-01" @default.
• W2078313885 modified "2023-10-17" @default.
• W2078313885 title "New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans" @default.
• W2078313885 cites W1495277562 @default.
• W2078313885 cites W1499079473 @default.
• W2078313885 cites W1540969441 @default.
• W2078313885 cites W1703928389 @default.
• W2078313885 cites W1963630241 @default.
• W2078313885 cites W1964889875 @default.
• W2078313885 cites W1966136057 @default.
• W2078313885 cites W1968854375 @default.
• W2078313885 cites W1979516391 @default.
• W2078313885 cites W1985362971 @default.
• W2078313885 cites W1986576876 @default.
• W2078313885 cites W1987811475 @default.
• W2078313885 cites W1992074719 @default.
• W2078313885 cites W1993288925 @default.
• W2078313885 cites W2001936817 @default.
• W2078313885 cites W2002220099 @default.
• W2078313885 cites W2005228725 @default.
• W2078313885 cites W2006173725 @default.
• W2078313885 cites W2006345440 @default.
• W2078313885 cites W2011465945 @default.
• W2078313885 cites W2015865718 @default.
• W2078313885 cites W2016173377 @default.
• W2078313885 cites W2016403923 @default.
• W2078313885 cites W2019164797 @default.
• W2078313885 cites W2019500639 @default.
• W2078313885 cites W2020839318 @default.
• W2078313885 cites W2021837980 @default.
• W2078313885 cites W2022374483 @default.
• W2078313885 cites W2023204919 @default.
• W2078313885 cites W2023205468 @default.
• W2078313885 cites W2033316296 @default.
• W2078313885 cites W2035397219 @default.
• W2078313885 cites W2035633979 @default.
• W2078313885 cites W2040389848 @default.
• W2078313885 cites W2048116738 @default.
• W2078313885 cites W2049544574 @default.
• W2078313885 cites W2050477306 @default.
• W2078313885 cites W2058816652 @default.
• W2078313885 cites W2061041720 @default.
• W2078313885 cites W2061187312 @default.
• W2078313885 cites W2062502027 @default.
• W2078313885 cites W2063807032 @default.
• W2078313885 cites W2064912476 @default.
• W2078313885 cites W2065271760 @default.
• W2078313885 cites W2067761581 @default.
• W2078313885 cites W2067847949 @default.
• W2078313885 cites W2068818952 @default.
• W2078313885 cites W2069708136 @default.
• W2078313885 cites W2074493061 @default.
• W2078313885 cites W2077073522 @default.
• W2078313885 cites W2082393218 @default.
• W2078313885 cites W2090329295 @default.
• W2078313885 cites W2092585293 @default.
• W2078313885 cites W2095036452 @default.
• W2078313885 cites W2096697954 @default.
• W2078313885 cites W2097128462 @default.
• W2078313885 cites W2099326239 @default.
• W2078313885 cites W2103546861 @default.
• W2078313885 cites W2107344829 @default.
• W2078313885 cites W2107611498 @default.
• W2078313885 cites W2111211467 @default.
• W2078313885 cites W2111305712 @default.
• W2078313885 cites W2112636046 @default.
• W2078313885 cites W2113515775 @default.
• W2078313885 cites W2118687644 @default.
• W2078313885 cites W2119990334 @default.
• W2078313885 cites W2120960764 @default.
• W2078313885 cites W2126525419 @default.
• W2078313885 cites W2128983351 @default.
• W2078313885 cites W2130189270 @default.
• W2078313885 cites W2132632499 @default.
• W2078313885 cites W2133260119 @default.
• W2078313885 cites W2134196182 @default.
• W2078313885 cites W2134797741 @default.
• W2078313885 cites W2141431840 @default.
• W2078313885 cites W2142668354 @default.
• W2078313885 cites W2144654387 @default.
• W2078313885 cites W2151686341 @default.
• W2078313885 cites W2153327500 @default.
• W2078313885 cites W2154035365 @default.
• W2078313885 cites W2163389924 @default.
• W2078313885 cites W2166430034 @default.
• W2078313885 cites W4254275792 @default.
• W2078313885 cites W4376848280 @default.
• W2078313885 doi "https://doi.org/10.1016/j.ygcen.2014.09.004" @default.
• W2078313885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25230393" @default.
• W2078313885 hasPublicationYear "2014" @default.
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