Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078322468> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2078322468 abstract "Spinocerebellar ataxia 12 (SCA12) is a unique dominant type of ataxia characterized by early and prominent action tremors, memory deficit, neuropathy, dysarthria, etc. The expansion of DNA triplet (CAG) repeats in 5'UTR of PPP2R2B gene appears to be the cause for the pathogenesis of the neurodegenerative disorder, SCA12. The objective of the current study was to identify the aberrantly expressed plasma proteins for their potential application in therapy or diagnosis/prognosis of SCA12. Sixty-two clinically suspected patients were assessed using International Co-operative Ataxia Rating Scale (ICARS) and genetic confirmation was done using PCR followed by DNA sequencing. Twenty patients who were genetically confirmed were included in the study. 2D-DIGE analyses of plasma proteins of SCA12 patients revealed 14 differentially expressed protein spots, which were confirmed as nine proteins by LC-MS/MS. The 6 downregulated and 3 upregulated proteins are known to have physiological role in transport (thyroxin and retinol to brain), lipid metabolism, memory, scavenging of free haemoglobin, etc. Altered expression of some of the proteins of interest, transthyretin, haptaglobin, apolipoprotein C-II, apolipoprotein C-III are indicative of clinical manifestations such as neuropathy, cognitive impairment and altered lipid metabolism in SCA12." @default.
- W2078322468 created "2016-06-24" @default.
- W2078322468 creator A5004024501 @default.
- W2078322468 creator A5048543070 @default.
- W2078322468 creator A5061451138 @default.
- W2078322468 date "2012-06-01" @default.
- W2078322468 modified "2023-09-25" @default.
- W2078322468 title "Identification and quantification of differentially expressed proteins in plasma of spinocerebellar ataxia type 12" @default.
- W2078322468 cites W1513749224 @default.
- W2078322468 cites W16048961 @default.
- W2078322468 cites W1967200471 @default.
- W2078322468 cites W1970744664 @default.
- W2078322468 cites W1981145789 @default.
- W2078322468 cites W1981637156 @default.
- W2078322468 cites W1984975190 @default.
- W2078322468 cites W2005426753 @default.
- W2078322468 cites W2009329139 @default.
- W2078322468 cites W2017632809 @default.
- W2078322468 cites W2019928525 @default.
- W2078322468 cites W2019983375 @default.
- W2078322468 cites W2033545352 @default.
- W2078322468 cites W2037122963 @default.
- W2078322468 cites W2037183484 @default.
- W2078322468 cites W2038258760 @default.
- W2078322468 cites W2043288745 @default.
- W2078322468 cites W2051186583 @default.
- W2078322468 cites W2063529980 @default.
- W2078322468 cites W2064182774 @default.
- W2078322468 cites W2064652091 @default.
- W2078322468 cites W2066685891 @default.
- W2078322468 cites W2090207532 @default.
- W2078322468 cites W2103880742 @default.
- W2078322468 cites W2127133583 @default.
- W2078322468 cites W2131701468 @default.
- W2078322468 cites W2172227531 @default.
- W2078322468 cites W978431966 @default.
- W2078322468 cites W2017179724 @default.
- W2078322468 doi "https://doi.org/10.1016/j.neures.2012.03.002" @default.
- W2078322468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22426495" @default.
- W2078322468 hasPublicationYear "2012" @default.
- W2078322468 type Work @default.
- W2078322468 sameAs 2078322468 @default.
- W2078322468 citedByCount "8" @default.
- W2078322468 countsByYear W20783224682013 @default.
- W2078322468 countsByYear W20783224682014 @default.
- W2078322468 countsByYear W20783224682018 @default.
- W2078322468 countsByYear W20783224682019 @default.
- W2078322468 countsByYear W20783224682021 @default.
- W2078322468 countsByYear W20783224682023 @default.
- W2078322468 crossrefType "journal-article" @default.
- W2078322468 hasAuthorship W2078322468A5004024501 @default.
- W2078322468 hasAuthorship W2078322468A5048543070 @default.
- W2078322468 hasAuthorship W2078322468A5061451138 @default.
- W2078322468 hasConcept C121157162 @default.
- W2078322468 hasConcept C126322002 @default.
- W2078322468 hasConcept C134018914 @default.
- W2078322468 hasConcept C169760540 @default.
- W2078322468 hasConcept C2776925932 @default.
- W2078322468 hasConcept C2779134260 @default.
- W2078322468 hasConcept C2779500118 @default.
- W2078322468 hasConcept C2780906641 @default.
- W2078322468 hasConcept C2780942790 @default.
- W2078322468 hasConcept C71924100 @default.
- W2078322468 hasConcept C86803240 @default.
- W2078322468 hasConceptScore W2078322468C121157162 @default.
- W2078322468 hasConceptScore W2078322468C126322002 @default.
- W2078322468 hasConceptScore W2078322468C134018914 @default.
- W2078322468 hasConceptScore W2078322468C169760540 @default.
- W2078322468 hasConceptScore W2078322468C2776925932 @default.
- W2078322468 hasConceptScore W2078322468C2779134260 @default.
- W2078322468 hasConceptScore W2078322468C2779500118 @default.
- W2078322468 hasConceptScore W2078322468C2780906641 @default.
- W2078322468 hasConceptScore W2078322468C2780942790 @default.
- W2078322468 hasConceptScore W2078322468C71924100 @default.
- W2078322468 hasConceptScore W2078322468C86803240 @default.
- W2078322468 hasLocation W20783224681 @default.
- W2078322468 hasLocation W20783224682 @default.
- W2078322468 hasOpenAccess W2078322468 @default.
- W2078322468 hasPrimaryLocation W20783224681 @default.
- W2078322468 hasRelatedWork W1617225148 @default.
- W2078322468 hasRelatedWork W2023283117 @default.
- W2078322468 hasRelatedWork W2031642818 @default.
- W2078322468 hasRelatedWork W2072917172 @default.
- W2078322468 hasRelatedWork W2084274029 @default.
- W2078322468 hasRelatedWork W2087935783 @default.
- W2078322468 hasRelatedWork W2088617309 @default.
- W2078322468 hasRelatedWork W2102100901 @default.
- W2078322468 hasRelatedWork W2159217600 @default.
- W2078322468 hasRelatedWork W2166041505 @default.
- W2078322468 isParatext "false" @default.
- W2078322468 isRetracted "false" @default.
- W2078322468 magId "2078322468" @default.
- W2078322468 workType "article" @default.