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• W2078323166 endingPage "1078" @default.
• W2078323166 startingPage "1070" @default.
• W2078323166 abstract "Studies of epithelial cancers (i.e., carcinomas) traditionally focused on transformation of the epithelium (i.e., the cancer cells) and how aberrant signaling within the cancer cells modulates the surrounding tissue of origin. In more recent decades, the normal cells, blood vessels, molecules, and extracellular components that surround the tumor cells, collectively known as the “tumor microenvironment” or “stroma”, have received increasing attention and are now thought to be key regulators of tumor initiation and progression. Of particular relevance to the work reviewed herein are the fibroblasts, which make up the major cell type within the microenvironment of most carcinomas. Due to their inherent heterogeneity, plasticity, and function, it is perhaps not surprising that fibroblasts are ideal modulators of normal and cancerous epithelium; however, these aspects also present challenges if we are to interrupt their tumor-supportive functions. Here, we review the current body of knowledge and the many questions that still remain about the special entity known as the cancer-associated fibroblast. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. ► Form and function — normal, activated, and cancer-associated fibroblasts ► Cancer-associated fibroblasts — heterogeneity ► Fibroblasts in cancer pathophysiology ► Tracing the origins of CAFs ► Interactions in the tumor microenvironment and CAFs as a clinical entity" @default.
• W2078323166 created "2016-06-24" @default.
• W2078323166 creator A5031913804 @default.
• W2078323166 creator A5059726837 @default.
• W2078323166 creator A5077605428 @default.
• W2078323166 date "2013-07-01" @default.
• W2078323166 modified "2023-09-29" @default.
• W2078323166 title "Fibroblasts as architects of cancer pathogenesis" @default.
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