Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078325390> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2078325390 endingPage "138" @default.
- W2078325390 startingPage "136" @default.
- W2078325390 abstract "Fifty febrile, granulocytopenic allogeneic bone marrow transplant patients receiving prophylactic trimethoprim-sulfamethoxazole were randomized to one of two empirical antibiotic regimens to determine whether a shortened course of empirical therapy was beneficial. Of the 50 patients, 25 received empirical tobramycin and ticarcillin for only 3 days, and 25 were maintained on empirical tobramycin and ticarcillin until they were afebrile and no longer granulocytopenic. Although the incidence of bacterial infections in the two groups was not statistically significantly different, almost twice as many bacterial infections were observed in the group that received the short course of empirical therapy. Furthermore, because of the high incidence of bacterial infection and clinical concerns about occult bacterial sepsis, within 2 weeks of the randomization the overall use of parenteral antibacterial agents was similar in both groups. The incidence of invasive fungal disease and the use of amphotericin B therapy were similar in both groups. The results of this study suggest that little clinical benefit is likely to be seen in bone marrow transplant patients treated with short-course empirical tobramycin and ticarcillin, despite the administration of prophylactic trimethoprim-sulfamethoxazole, and emphasize the need for new strategies to prevent infections with gram-positive and trimethoprim-sulfamethoxazole-resistant gram-negative bacteria in these patients." @default.
- W2078325390 created "2016-06-24" @default.
- W2078325390 creator A5011726019 @default.
- W2078325390 creator A5046039221 @default.
- W2078325390 creator A5061747256 @default.
- W2078325390 creator A5071051461 @default.
- W2078325390 creator A5079435976 @default.
- W2078325390 creator A5091177221 @default.
- W2078325390 date "1984-08-01" @default.
- W2078325390 modified "2023-09-27" @default.
- W2078325390 title "Empirical antibacterial therapy in febrile, granulocytopenic bone marrow transplant patients" @default.
- W2078325390 cites W2007848599 @default.
- W2078325390 cites W2031588848 @default.
- W2078325390 cites W2036845758 @default.
- W2078325390 cites W2114208000 @default.
- W2078325390 cites W2412012008 @default.
- W2078325390 doi "https://doi.org/10.1128/aac.26.2.136" @default.
- W2078325390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/284106" @default.
- W2078325390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6385835" @default.
- W2078325390 hasPublicationYear "1984" @default.
- W2078325390 type Work @default.
- W2078325390 sameAs 2078325390 @default.
- W2078325390 citedByCount "9" @default.
- W2078325390 crossrefType "journal-article" @default.
- W2078325390 hasAuthorship W2078325390A5011726019 @default.
- W2078325390 hasAuthorship W2078325390A5046039221 @default.
- W2078325390 hasAuthorship W2078325390A5061747256 @default.
- W2078325390 hasAuthorship W2078325390A5071051461 @default.
- W2078325390 hasAuthorship W2078325390A5079435976 @default.
- W2078325390 hasAuthorship W2078325390A5091177221 @default.
- W2078325390 hasBestOaLocation W20783253902 @default.
- W2078325390 hasConcept C120665830 @default.
- W2078325390 hasConcept C121332964 @default.
- W2078325390 hasConcept C126322002 @default.
- W2078325390 hasConcept C141071460 @default.
- W2078325390 hasConcept C2775832221 @default.
- W2078325390 hasConcept C2776083883 @default.
- W2078325390 hasConcept C2778974779 @default.
- W2078325390 hasConcept C2779425571 @default.
- W2078325390 hasConcept C2779631663 @default.
- W2078325390 hasConcept C2780728791 @default.
- W2078325390 hasConcept C501593827 @default.
- W2078325390 hasConcept C61511704 @default.
- W2078325390 hasConcept C71924100 @default.
- W2078325390 hasConcept C86803240 @default.
- W2078325390 hasConcept C89423630 @default.
- W2078325390 hasConcept C94665300 @default.
- W2078325390 hasConceptScore W2078325390C120665830 @default.
- W2078325390 hasConceptScore W2078325390C121332964 @default.
- W2078325390 hasConceptScore W2078325390C126322002 @default.
- W2078325390 hasConceptScore W2078325390C141071460 @default.
- W2078325390 hasConceptScore W2078325390C2775832221 @default.
- W2078325390 hasConceptScore W2078325390C2776083883 @default.
- W2078325390 hasConceptScore W2078325390C2778974779 @default.
- W2078325390 hasConceptScore W2078325390C2779425571 @default.
- W2078325390 hasConceptScore W2078325390C2779631663 @default.
- W2078325390 hasConceptScore W2078325390C2780728791 @default.
- W2078325390 hasConceptScore W2078325390C501593827 @default.
- W2078325390 hasConceptScore W2078325390C61511704 @default.
- W2078325390 hasConceptScore W2078325390C71924100 @default.
- W2078325390 hasConceptScore W2078325390C86803240 @default.
- W2078325390 hasConceptScore W2078325390C89423630 @default.
- W2078325390 hasConceptScore W2078325390C94665300 @default.
- W2078325390 hasIssue "2" @default.
- W2078325390 hasLocation W20783253901 @default.
- W2078325390 hasLocation W20783253902 @default.
- W2078325390 hasLocation W20783253903 @default.
- W2078325390 hasOpenAccess W2078325390 @default.
- W2078325390 hasPrimaryLocation W20783253901 @default.
- W2078325390 hasRelatedWork W1537048246 @default.
- W2078325390 hasRelatedWork W2023693007 @default.
- W2078325390 hasRelatedWork W2064739013 @default.
- W2078325390 hasRelatedWork W2078325390 @default.
- W2078325390 hasRelatedWork W2139186193 @default.
- W2078325390 hasRelatedWork W2359096203 @default.
- W2078325390 hasRelatedWork W2369946014 @default.
- W2078325390 hasRelatedWork W2404235239 @default.
- W2078325390 hasRelatedWork W3136803040 @default.
- W2078325390 hasRelatedWork W4239075073 @default.
- W2078325390 hasVolume "26" @default.
- W2078325390 isParatext "false" @default.
- W2078325390 isRetracted "false" @default.
- W2078325390 magId "2078325390" @default.
- W2078325390 workType "article" @default.