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• W2078327154 abstract "Polychlorinated biphenyls (PCBs) are man-made ubiquitous pollutants that have detrimental effects on reproduction and endocrine functions in a variety of species. In the present study, estrogenic and toxic effects of PCBs on embryonic chicken ovarian development were evaluated by a germ-somatic cell co-culture system. Ovarian cells were cultured in serum-free medium and challenged with a mixture of PCBs (Aroclor 1254). Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) reduction and lactate dehydrogenase (LDH) release. Results showed that lower PCBs (0.1-1 microg/ml) manifested mainly estrogenic effect to stimulate germ cell proliferation, while higher PCBs (10 microg/ml) imposed severe toxicity on germ and somatic cells. The toxic effect of PCBs could be attenuated by an antioxidant tocopherol. PCBs induced condensed nuclear chromosome in ovarian cells and caused cell exfoliation and breakdown within initial hours of treatment. After 24 h, the estrogenic effect of PCBs began to exhibit and the survived germ cells manifested proliferation. Inhibition of the estrogenic effect of PCBs by tamoxifen led to increased toxicity on germ cells and somatic cells. These results indicate that PCBs exposure may interfere with ovarian germ cell proliferation and cause reproductive disorder via both toxic and estrogenic actions in embryonic chickens." @default.
• W2078327154 created "2016-06-24" @default.
• W2078327154 creator A5007842960 @default.
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• W2078327154 date "2004-11-01" @default.
• W2078327154 modified "2023-09-27" @default.
• W2078327154 title "Estrogenic and toxic effects of polychlorinated biphenyls on cultured ovarian germ cells of embryonic chickens" @default.
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• W2078327154 doi "https://doi.org/10.1016/j.reprotox.2004.06.004" @default.
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