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- W2078330966 abstract "A series of 4-nitroimidazole derivatives bearing substituted piperazines (5, 8, 9, 12, 14, 16, 17, and 19 - 21) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. All compounds are inactive, except compound 21 which showed inhibition of HIV-1 with EC 50 0.20 μg/mL, and therapeutic indexes (SI) of 12." @default.
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- W2078330966 date "2007-04-01" @default.
- W2078330966 modified "2023-10-17" @default.
- W2078330966 title "Nitroimidazoles, Part 3. Synthesis and anti-HIV Activity of New N-Alkyl-4-nitroimidazoles Bearing Benzothiazole and Benzoxazole Backbones" @default.
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- W2078330966 doi "https://doi.org/10.1515/znb-2007-0406" @default.
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