Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078331982> ?p ?o ?g. }
- W2078331982 endingPage "22071" @default.
- W2078331982 startingPage "22066" @default.
- W2078331982 abstract "Every polyketide synthase module has an acyl carrier protein (ACP) and a ketosynthase (KS) domain that collaborate to catalyze chain elongation. The same ACP then engages the KS domain of the next module to facilitate chain transfer. Understanding the mechanism for this orderly progress of the growing polyketide chain represents a fundamental challenge in assembly line enzymology. Using both experimental and computational approaches, the molecular basis for KS–ACP interactions in the 6-deoxyerythronolide B synthase has been decoded. Surprisingly, KS–ACP recognition is controlled at different interfaces during chain elongation versus chain transfer. In fact, chain elongation is controlled at a docking site remote from the catalytic center. Not only do our findings reveal a new principle in the modular control of polyketide antibiotic biosynthesis, they also provide a rationale for the mandatory homodimeric structure of polyketide synthases, in contrast to the monomeric nonribosomal peptide synthetases." @default.
- W2078331982 created "2016-06-24" @default.
- W2078331982 creator A5038399044 @default.
- W2078331982 creator A5063330217 @default.
- W2078331982 creator A5089567240 @default.
- W2078331982 creator A5089983022 @default.
- W2078331982 date "2010-12-02" @default.
- W2078331982 modified "2023-09-23" @default.
- W2078331982 title "Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase" @default.
- W2078331982 cites W1968430567 @default.
- W2078331982 cites W1973421302 @default.
- W2078331982 cites W1979366690 @default.
- W2078331982 cites W1982793579 @default.
- W2078331982 cites W1985330214 @default.
- W2078331982 cites W1988750758 @default.
- W2078331982 cites W1995816575 @default.
- W2078331982 cites W1998307795 @default.
- W2078331982 cites W2000254868 @default.
- W2078331982 cites W2001396254 @default.
- W2078331982 cites W2002110958 @default.
- W2078331982 cites W2005042667 @default.
- W2078331982 cites W2009629410 @default.
- W2078331982 cites W2011215403 @default.
- W2078331982 cites W2012871310 @default.
- W2078331982 cites W2018766725 @default.
- W2078331982 cites W2025225891 @default.
- W2078331982 cites W2025889664 @default.
- W2078331982 cites W2029582401 @default.
- W2078331982 cites W2030805687 @default.
- W2078331982 cites W2031541469 @default.
- W2078331982 cites W2033443315 @default.
- W2078331982 cites W2034511497 @default.
- W2078331982 cites W2039285595 @default.
- W2078331982 cites W2047399603 @default.
- W2078331982 cites W2047895750 @default.
- W2078331982 cites W2054474037 @default.
- W2078331982 cites W2059504647 @default.
- W2078331982 cites W2059719012 @default.
- W2078331982 cites W2074137186 @default.
- W2078331982 cites W2075947519 @default.
- W2078331982 cites W2087997529 @default.
- W2078331982 cites W2124371326 @default.
- W2078331982 cites W2131900949 @default.
- W2078331982 cites W2143662606 @default.
- W2078331982 cites W2151460035 @default.
- W2078331982 cites W2152997175 @default.
- W2078331982 cites W2155143235 @default.
- W2078331982 cites W2155201844 @default.
- W2078331982 cites W2165565773 @default.
- W2078331982 cites W2169595886 @default.
- W2078331982 cites W2170889268 @default.
- W2078331982 doi "https://doi.org/10.1073/pnas.1014081107" @default.
- W2078331982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3009775" @default.
- W2078331982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21127271" @default.
- W2078331982 hasPublicationYear "2010" @default.
- W2078331982 type Work @default.
- W2078331982 sameAs 2078331982 @default.
- W2078331982 citedByCount "82" @default.
- W2078331982 countsByYear W20783319822012 @default.
- W2078331982 countsByYear W20783319822013 @default.
- W2078331982 countsByYear W20783319822014 @default.
- W2078331982 countsByYear W20783319822015 @default.
- W2078331982 countsByYear W20783319822016 @default.
- W2078331982 countsByYear W20783319822017 @default.
- W2078331982 countsByYear W20783319822018 @default.
- W2078331982 countsByYear W20783319822019 @default.
- W2078331982 countsByYear W20783319822020 @default.
- W2078331982 countsByYear W20783319822021 @default.
- W2078331982 countsByYear W20783319822022 @default.
- W2078331982 countsByYear W20783319822023 @default.
- W2078331982 crossrefType "journal-article" @default.
- W2078331982 hasAuthorship W2078331982A5038399044 @default.
- W2078331982 hasAuthorship W2078331982A5063330217 @default.
- W2078331982 hasAuthorship W2078331982A5089567240 @default.
- W2078331982 hasAuthorship W2078331982A5089983022 @default.
- W2078331982 hasBestOaLocation W20783319822 @default.
- W2078331982 hasConcept C112243037 @default.
- W2078331982 hasConcept C181199279 @default.
- W2078331982 hasConcept C185592680 @default.
- W2078331982 hasConcept C2777379556 @default.
- W2078331982 hasConcept C2777763344 @default.
- W2078331982 hasConcept C2778635478 @default.
- W2078331982 hasConcept C2780786045 @default.
- W2078331982 hasConcept C553450214 @default.
- W2078331982 hasConcept C55493867 @default.
- W2078331982 hasConcept C71240020 @default.
- W2078331982 hasConcept C86803240 @default.
- W2078331982 hasConceptScore W2078331982C112243037 @default.
- W2078331982 hasConceptScore W2078331982C181199279 @default.
- W2078331982 hasConceptScore W2078331982C185592680 @default.
- W2078331982 hasConceptScore W2078331982C2777379556 @default.
- W2078331982 hasConceptScore W2078331982C2777763344 @default.
- W2078331982 hasConceptScore W2078331982C2778635478 @default.
- W2078331982 hasConceptScore W2078331982C2780786045 @default.
- W2078331982 hasConceptScore W2078331982C553450214 @default.
- W2078331982 hasConceptScore W2078331982C55493867 @default.
- W2078331982 hasConceptScore W2078331982C71240020 @default.
- W2078331982 hasConceptScore W2078331982C86803240 @default.