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- W2078332608 abstract "Toll-like receptor 2 (TLR2) serves as a co-stimulatory receptor for human T cells by enhancing T cell receptor (TCR)-induced cytokine production and proliferation. However, it is unknown where signals from the TCR and TLR2 converge to enhance T cell activation. To address this gap, we examined changes in TCR-induced signaling following concurrent TLR2 activation in human T cells. Both proximal TCR-mediated signaling and early NFκB activation were not enhanced by TCR andTLR2 co-activation, potentially due to the association of TLR2 with TLR10. Instead, TLR2 co-induction did augment Akt and Erk1/Erk2 activation in human T cells. These findings demonstrate that TLR2 activates distinct signaling pathways in human T cells and suggest that alterations in expression of TLR2 co-receptors may contribute to aberrant T cell responses." @default.
- W2078332608 created "2016-06-24" @default.
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- W2078332608 date "2013-03-01" @default.
- W2078332608 modified "2023-10-16" @default.
- W2078332608 title "Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells" @default.
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- W2078332608 doi "https://doi.org/10.1016/j.cellsig.2012.11.026" @default.
- W2078332608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3883577" @default.
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