Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078336430> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2078336430 endingPage "176" @default.
- W2078336430 startingPage "169" @default.
- W2078336430 abstract "The depression of vasoconstrictor responsiveness caused by bacterial lipopolysaccharide (LPS) is mediated, in part, by the induction of nitric oxide synthase (NOS) and the resultant increase in nitric oxide production by vascular smooth muscle. The present study evaluated the ability of the antioxidant, diethyldithiocarbamate (DDTC), to attenuate the LPS-stimulated induction of NOS in cultured vascular smooth muscle cells (VSMC) and the depression of in vitro vascular reactivity caused by LPS administration to rats. The LPS-stimulated increase in nitrite production by cultured VSMC was inhibited 85% by DDTC (100 μM). When VSMC were stimulated with a combination of LPS, interferon-γ (INF) and tumor necrosis factor (TNF) nitrite production was 5-fold greater than with LPS alone. DDTC inhibited 49% of the increase caused by LPS plus INF and TNF. Aortic rings taken from animals injected with LPS showed a depression of maximum force in response to phenylephrine which was reversed by inhibition of NOS activity. Pretreatment of animals with DDTC attenuated this depression of vascular reactivity. The DDTC treatment did not reduce the increase in serum TNF levels caused by LPS. These results suggest that DDTC can attenuate the LPS-stimulated induction of NOS in vascular smooth muscle and may thereby ameliorate the impairment of vascular reactivity." @default.
- W2078336430 created "2016-06-24" @default.
- W2078336430 creator A5025767431 @default.
- W2078336430 creator A5051072125 @default.
- W2078336430 creator A5052327886 @default.
- W2078336430 creator A5080113540 @default.
- W2078336430 date "1995-06-01" @default.
- W2078336430 modified "2023-10-17" @default.
- W2078336430 title "Diethyldithiocarbamate ameliorates the effect of lipopolysaccharide on both increased nitrite production by vascular smooth muscle cells and decreased contractile response of aortic rings" @default.
- W2078336430 cites W1845759512 @default.
- W2078336430 cites W1963635146 @default.
- W2078336430 cites W1969726677 @default.
- W2078336430 cites W1985929162 @default.
- W2078336430 cites W1989306304 @default.
- W2078336430 cites W1990802251 @default.
- W2078336430 cites W2040622513 @default.
- W2078336430 cites W2058702543 @default.
- W2078336430 cites W2076946996 @default.
- W2078336430 cites W2091045350 @default.
- W2078336430 cites W2101392591 @default.
- W2078336430 cites W2127336451 @default.
- W2078336430 cites W2159002134 @default.
- W2078336430 cites W2159567970 @default.
- W2078336430 cites W2414350339 @default.
- W2078336430 doi "https://doi.org/10.1016/0024-3205(95)00257-7" @default.
- W2078336430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7541501" @default.
- W2078336430 hasPublicationYear "1995" @default.
- W2078336430 type Work @default.
- W2078336430 sameAs 2078336430 @default.
- W2078336430 citedByCount "9" @default.
- W2078336430 countsByYear W20783364302014 @default.
- W2078336430 countsByYear W20783364302021 @default.
- W2078336430 crossrefType "journal-article" @default.
- W2078336430 hasAuthorship W2078336430A5025767431 @default.
- W2078336430 hasAuthorship W2078336430A5051072125 @default.
- W2078336430 hasAuthorship W2078336430A5052327886 @default.
- W2078336430 hasAuthorship W2078336430A5080113540 @default.
- W2078336430 hasConcept C126322002 @default.
- W2078336430 hasConcept C134018914 @default.
- W2078336430 hasConcept C178790620 @default.
- W2078336430 hasConcept C17991360 @default.
- W2078336430 hasConcept C185592680 @default.
- W2078336430 hasConcept C2776179834 @default.
- W2078336430 hasConcept C2776384668 @default.
- W2078336430 hasConcept C2777622882 @default.
- W2078336430 hasConcept C2777663904 @default.
- W2078336430 hasConcept C2777952589 @default.
- W2078336430 hasConcept C2778754761 @default.
- W2078336430 hasConcept C2779395532 @default.
- W2078336430 hasConcept C2992686903 @default.
- W2078336430 hasConcept C519581460 @default.
- W2078336430 hasConcept C71924100 @default.
- W2078336430 hasConcept C84393581 @default.
- W2078336430 hasConcept C98274493 @default.
- W2078336430 hasConceptScore W2078336430C126322002 @default.
- W2078336430 hasConceptScore W2078336430C134018914 @default.
- W2078336430 hasConceptScore W2078336430C178790620 @default.
- W2078336430 hasConceptScore W2078336430C17991360 @default.
- W2078336430 hasConceptScore W2078336430C185592680 @default.
- W2078336430 hasConceptScore W2078336430C2776179834 @default.
- W2078336430 hasConceptScore W2078336430C2776384668 @default.
- W2078336430 hasConceptScore W2078336430C2777622882 @default.
- W2078336430 hasConceptScore W2078336430C2777663904 @default.
- W2078336430 hasConceptScore W2078336430C2777952589 @default.
- W2078336430 hasConceptScore W2078336430C2778754761 @default.
- W2078336430 hasConceptScore W2078336430C2779395532 @default.
- W2078336430 hasConceptScore W2078336430C2992686903 @default.
- W2078336430 hasConceptScore W2078336430C519581460 @default.
- W2078336430 hasConceptScore W2078336430C71924100 @default.
- W2078336430 hasConceptScore W2078336430C84393581 @default.
- W2078336430 hasConceptScore W2078336430C98274493 @default.
- W2078336430 hasIssue "2" @default.
- W2078336430 hasLocation W20783364301 @default.
- W2078336430 hasLocation W20783364302 @default.
- W2078336430 hasOpenAccess W2078336430 @default.
- W2078336430 hasPrimaryLocation W20783364301 @default.
- W2078336430 hasRelatedWork W196265488 @default.
- W2078336430 hasRelatedWork W1972918377 @default.
- W2078336430 hasRelatedWork W1985900017 @default.
- W2078336430 hasRelatedWork W1986555336 @default.
- W2078336430 hasRelatedWork W1998362519 @default.
- W2078336430 hasRelatedWork W2034415638 @default.
- W2078336430 hasRelatedWork W2051267793 @default.
- W2078336430 hasRelatedWork W2055860776 @default.
- W2078336430 hasRelatedWork W2065187752 @default.
- W2078336430 hasRelatedWork W2108732647 @default.
- W2078336430 hasVolume "57" @default.
- W2078336430 isParatext "false" @default.
- W2078336430 isRetracted "false" @default.
- W2078336430 magId "2078336430" @default.
- W2078336430 workType "article" @default.