Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078340161> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2078340161 endingPage "1164" @default.
- W2078340161 startingPage "1159" @default.
- W2078340161 abstract "A frequently employed strategy in drug discovery efforts is to replace aromatic rings in known active compounds with alternative aromatic moieties to create novel compounds with improved potency and/or adsorption, distribution, metabolism, excretion, and toxicity properties. Here we introduce MORPH, which is a simple software tool for systematically modifying aromatic rings in three-dimensional models of molecules without altering the coordinates of the nonhydrogen atoms in the rings. MORPH works on individual rings as well as fused ring systems and additionally provides the ability to filter out modified compounds which do not contain hydrogen-bond donors or acceptors at specific positions on the rings or contain more or less than the desired number of heteroatoms. The MORPH program and its application to two ligands extracted from cocrystal structures with cyclin-dependent kinase 2 (CDK2)/cyclin A and CDK2 are discussed below." @default.
- W2078340161 created "2016-06-24" @default.
- W2078340161 creator A5061926860 @default.
- W2078340161 creator A5064462016 @default.
- W2078340161 date "2010-05-18" @default.
- W2078340161 modified "2023-09-26" @default.
- W2078340161 title "MORPH: A New Tool for Ligand Design" @default.
- W2078340161 cites W1975972702 @default.
- W2078340161 cites W1983790923 @default.
- W2078340161 cites W2015728503 @default.
- W2078340161 cites W2023881920 @default.
- W2078340161 cites W2050458179 @default.
- W2078340161 cites W2051810242 @default.
- W2078340161 cites W2058098264 @default.
- W2078340161 cites W2065568989 @default.
- W2078340161 cites W2078412962 @default.
- W2078340161 cites W2084251502 @default.
- W2078340161 cites W2086254747 @default.
- W2078340161 cites W2089248273 @default.
- W2078340161 cites W2094120651 @default.
- W2078340161 cites W2130479394 @default.
- W2078340161 cites W2143223762 @default.
- W2078340161 cites W2147542160 @default.
- W2078340161 cites W2174570645 @default.
- W2078340161 cites W4213348607 @default.
- W2078340161 doi "https://doi.org/10.1021/ci9004964" @default.
- W2078340161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20481489" @default.
- W2078340161 hasPublicationYear "2010" @default.
- W2078340161 type Work @default.
- W2078340161 sameAs 2078340161 @default.
- W2078340161 citedByCount "9" @default.
- W2078340161 countsByYear W20783401612012 @default.
- W2078340161 countsByYear W20783401612013 @default.
- W2078340161 countsByYear W20783401612014 @default.
- W2078340161 countsByYear W20783401612016 @default.
- W2078340161 countsByYear W20783401612021 @default.
- W2078340161 countsByYear W20783401612022 @default.
- W2078340161 crossrefType "journal-article" @default.
- W2078340161 hasAuthorship W2078340161A5061926860 @default.
- W2078340161 hasAuthorship W2078340161A5064462016 @default.
- W2078340161 hasConcept C100687433 @default.
- W2078340161 hasConcept C112887158 @default.
- W2078340161 hasConcept C116569031 @default.
- W2078340161 hasConcept C170493617 @default.
- W2078340161 hasConcept C178790620 @default.
- W2078340161 hasConcept C185592680 @default.
- W2078340161 hasConcept C192386470 @default.
- W2078340161 hasConcept C20950531 @default.
- W2078340161 hasConcept C21951064 @default.
- W2078340161 hasConcept C2780378348 @default.
- W2078340161 hasConcept C32909587 @default.
- W2078340161 hasConcept C55493867 @default.
- W2078340161 hasConcept C71240020 @default.
- W2078340161 hasConcept C74187038 @default.
- W2078340161 hasConceptScore W2078340161C100687433 @default.
- W2078340161 hasConceptScore W2078340161C112887158 @default.
- W2078340161 hasConceptScore W2078340161C116569031 @default.
- W2078340161 hasConceptScore W2078340161C170493617 @default.
- W2078340161 hasConceptScore W2078340161C178790620 @default.
- W2078340161 hasConceptScore W2078340161C185592680 @default.
- W2078340161 hasConceptScore W2078340161C192386470 @default.
- W2078340161 hasConceptScore W2078340161C20950531 @default.
- W2078340161 hasConceptScore W2078340161C21951064 @default.
- W2078340161 hasConceptScore W2078340161C2780378348 @default.
- W2078340161 hasConceptScore W2078340161C32909587 @default.
- W2078340161 hasConceptScore W2078340161C55493867 @default.
- W2078340161 hasConceptScore W2078340161C71240020 @default.
- W2078340161 hasConceptScore W2078340161C74187038 @default.
- W2078340161 hasIssue "6" @default.
- W2078340161 hasLocation W20783401611 @default.
- W2078340161 hasLocation W20783401612 @default.
- W2078340161 hasOpenAccess W2078340161 @default.
- W2078340161 hasPrimaryLocation W20783401611 @default.
- W2078340161 hasRelatedWork W1522940047 @default.
- W2078340161 hasRelatedWork W2032782993 @default.
- W2078340161 hasRelatedWork W2039417035 @default.
- W2078340161 hasRelatedWork W2041981575 @default.
- W2078340161 hasRelatedWork W2305179561 @default.
- W2078340161 hasRelatedWork W2326418715 @default.
- W2078340161 hasRelatedWork W2504212939 @default.
- W2078340161 hasRelatedWork W2566812028 @default.
- W2078340161 hasRelatedWork W2940853498 @default.
- W2078340161 hasRelatedWork W4229077622 @default.
- W2078340161 hasVolume "50" @default.
- W2078340161 isParatext "false" @default.
- W2078340161 isRetracted "false" @default.
- W2078340161 magId "2078340161" @default.
- W2078340161 workType "article" @default.