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- W2078342513 abstract "The transfer of androgens from cytoplasm to nuclei has been studied in two animal model systems, the rat prostate and the Shionogi mouse mammary carcinoma. It has been found that androgens are incorporated into the prostatic nucleus by a regulated, selective process which appears to limit the type and amount of androgen transported across the nuclear membrane. In vivo under optimal conditions, about 60,000 molecules of androgen penetrate the nucleus before transport stops. In the presence of an adequate concentration of testosterone or dihydrotestosterone in cytoplasm, the transfer of these androgens into the nucleus proceeds rapidly and is virtually complete within 60 min. During this time 5000, or fewer, detectable androgen receptors (mol wt. 86,000) disappear from cytoplasm and 10,000 to 20,000 receptors (mol wt. 33,000) appear in the nucleus. Because of the relatively small number of detectable cytoplasmic receptors, it is possible that several molecules of androgen are transferred into the nucleus for each molecule of receptor that either disappears from the cytoplasm or appears in the nucleus. Investigation of the intracellular transport of androgens in several lines of Shionogi carcinoma cells has also furnished evidence of a correlation between the presence of receptors in cytoplasm and the ability to transfer androgens into the nucleus. Taken together the results of these studies suggest that the intranuclear concentration of androgens is regulated in part by cytoplasmic receptors, but they leave open the possibility that the control of androgen concentration in the nucleus may be achieved by an independent process which does not rely on androgen receptors." @default.
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- W2078342513 date "1975-05-01" @default.
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- W2078342513 title "The influence of androgen receptors on the concentration of androgens in nuclei of hormone-responsive cells" @default.
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- W2078342513 doi "https://doi.org/10.1016/0022-4731(75)90034-5" @default.
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