FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078342606> ?p ?o ?g. }

• W2078342606 endingPage "116" @default.
• W2078342606 startingPage "106" @default.
• W2078342606 abstract "Our previous studies found that 4 compounds, namely pseudohypericin, amentoflavone, quercetin, and chlorogenic acid, in Hypericum perforatum ethanol extract synergistically inhibited lipopolysaccharide (LPS)-induced macrophage production of prostaglandin E2 (PGE2). Microarray studies led us to hypothesize that these compounds inhibited PGE2 production by activating suppressor of cytokine signaling 3 (SOCS3). In the current study, siRNA was used to knockdown expression of SOCS3 in RAW 264.7 macrophages and investigated the impact of H. perforatum extract and the 4 compounds on inflammatory mediators and cytokines. It was found that the SOCS3 knockdown significantly compromised the inhibition of PGE2 and nitric oxide (NO) by the 4 compounds, but not by the extract. The 4 compounds, but not the extract, decreased interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), while both lowered interleukine-1β. SOCS3 knockdown further decreased IL-6 and TNF-α. Pseudohypericin was the major contributor to the PGE2 and NO inhibition in cells treated with the 4 compounds, and its activity was lost with the SOCS3 knockdown. Cyclooxygenase-2 (COX-2) and inducible NO synthase protein expression were not altered by the treatments, while COX-2 activity was decreased by the extract and the 4 compounds and increased by SOCS3 knockdown. In summary, it was demonstrated that the 4 compounds inhibited LPS-induced PGE2 and NO through SOCS3 activation. The reduction of PGE2 can be partially attributed to COX-2 enzyme activity, which was significantly elevated with SOCS3 knockdown. At the same time, these results also suggest that constituents in H. perforatum extract were alleviating LPS-induced macrophage response through SOCS3 independent mechanisms." @default.
• W2078342606 created "2016-06-24" @default.
• W2078342606 creator A5014796492 @default.
• W2078342606 creator A5040617785 @default.
• W2078342606 creator A5054990859 @default.
• W2078342606 creator A5058220619 @default.
• W2078342606 creator A5066644036 @default.
• W2078342606 creator A5090120915 @default.
• W2078342606 date "2012-04-01" @default.
• W2078342606 modified "2023-09-23" @default.
• W2078342606 title "The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3" @default.
• W2078342606 cites W1926521347 @default.
• W2078342606 cites W1979114732 @default.
• W2078342606 cites W1987631000 @default.
• W2078342606 cites W1988875770 @default.
• W2078342606 cites W2009893225 @default.
• W2078342606 cites W2011837553 @default.
• W2078342606 cites W2013363382 @default.
• W2078342606 cites W2017666089 @default.
• W2078342606 cites W2033853755 @default.
• W2078342606 cites W2036582783 @default.
• W2078342606 cites W2043192125 @default.
• W2078342606 cites W2047656753 @default.
• W2078342606 cites W2085701551 @default.
• W2078342606 cites W2089055807 @default.
• W2078342606 cites W2093442991 @default.
• W2078342606 cites W2095455546 @default.
• W2078342606 cites W2096313549 @default.
• W2078342606 cites W2097188626 @default.
• W2078342606 cites W2120247510 @default.
• W2078342606 cites W2126439584 @default.
• W2078342606 cites W2131936676 @default.
• W2078342606 cites W2143364214 @default.
• W2078342606 cites W2152127772 @default.
• W2078342606 cites W2155093601 @default.
• W2078342606 cites W2159659449 @default.
• W2078342606 cites W4252406065 @default.
• W2078342606 cites W1999498517 @default.
• W2078342606 doi "https://doi.org/10.1016/j.phytochem.2011.12.001" @default.
• W2078342606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3294117" @default.
• W2078342606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22245632" @default.
• W2078342606 hasPublicationYear "2012" @default.
• W2078342606 type Work @default.
• W2078342606 sameAs 2078342606 @default.
• W2078342606 citedByCount "28" @default.
• W2078342606 countsByYear W20783426062012 @default.
• W2078342606 countsByYear W20783426062013 @default.
• W2078342606 countsByYear W20783426062014 @default.
• W2078342606 countsByYear W20783426062015 @default.
• W2078342606 countsByYear W20783426062016 @default.
• W2078342606 countsByYear W20783426062017 @default.
• W2078342606 countsByYear W20783426062018 @default.
• W2078342606 countsByYear W20783426062019 @default.
• W2078342606 countsByYear W20783426062021 @default.
• W2078342606 countsByYear W20783426062023 @default.
• W2078342606 crossrefType "journal-article" @default.
• W2078342606 hasAuthorship W2078342606A5014796492 @default.
• W2078342606 hasAuthorship W2078342606A5040617785 @default.
• W2078342606 hasAuthorship W2078342606A5054990859 @default.
• W2078342606 hasAuthorship W2078342606A5058220619 @default.
• W2078342606 hasAuthorship W2078342606A5066644036 @default.
• W2078342606 hasAuthorship W2078342606A5090120915 @default.
• W2078342606 hasBestOaLocation W20783426062 @default.
• W2078342606 hasConcept C126042315 @default.
• W2078342606 hasConcept C134018914 @default.
• W2078342606 hasConcept C173396325 @default.
• W2078342606 hasConcept C178790620 @default.
• W2078342606 hasConcept C17991360 @default.
• W2078342606 hasConcept C181199279 @default.
• W2078342606 hasConcept C185592680 @default.
• W2078342606 hasConcept C190283241 @default.
• W2078342606 hasConcept C203014093 @default.
• W2078342606 hasConcept C2776651039 @default.
• W2078342606 hasConcept C2776914184 @default.
• W2078342606 hasConcept C2777622882 @default.
• W2078342606 hasConcept C2777956040 @default.
• W2078342606 hasConcept C2778690821 @default.
• W2078342606 hasConcept C2778754761 @default.
• W2078342606 hasConcept C2778923194 @default.
• W2078342606 hasConcept C519581460 @default.
• W2078342606 hasConcept C55493867 @default.
• W2078342606 hasConcept C62478195 @default.
• W2078342606 hasConcept C86803240 @default.
• W2078342606 hasConcept C98274493 @default.
• W2078342606 hasConceptScore W2078342606C126042315 @default.
• W2078342606 hasConceptScore W2078342606C134018914 @default.
• W2078342606 hasConceptScore W2078342606C173396325 @default.
• W2078342606 hasConceptScore W2078342606C178790620 @default.
• W2078342606 hasConceptScore W2078342606C17991360 @default.
• W2078342606 hasConceptScore W2078342606C181199279 @default.
• W2078342606 hasConceptScore W2078342606C185592680 @default.
• W2078342606 hasConceptScore W2078342606C190283241 @default.
• W2078342606 hasConceptScore W2078342606C203014093 @default.
• W2078342606 hasConceptScore W2078342606C2776651039 @default.
• W2078342606 hasConceptScore W2078342606C2776914184 @default.
• W2078342606 hasConceptScore W2078342606C2777622882 @default.
• W2078342606 hasConceptScore W2078342606C2777956040 @default.
• W2078342606 hasConceptScore W2078342606C2778690821 @default.

• next