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- W2078343399 abstract "Methamphetamine (METH) dependence is frequently comorbid with HIV infection. Both factors are independently characterized by inhibitory deficits, which may manifest as increased motor activity, inappropriate perseverative behavior, and elevated exploratory responses to novel stimuli, but the effect of combined METH exposure and HIV is not well understood. In this study, we administered a chronic escalation/binge regimen of METH or vehicle treatment to wildtype (WT) or transgenic (tg) mice expressing the HIV-1 gp120 envelope protein and quantified disinhibition during the 7 days following drug withdrawal. We hypothesized that gp120tg mice administered chronic METH would exhibit more pronounced inhibitory deficits compared to vehicle-treated WT or gp120tg animals. Our results showed that METH treatment alone increased novel object interaction while female METH-treated gp120tg mice exhibited the highest level of exploration (holepoking) compared to other female mice. Transgenic mice exhibited fewer rears relative to WT, slightly less locomotion, and also demonstrated a trend toward more perseverative motor patterns. In summary, both METH treatment and gp120 expression may modify inhibition, but such effects are selective and dependent upon variations in age and sex that could impact dopamine and frontostriatal function. These findings illustrate the need to improve our knowledge about the combined effects of HIV and substance use and facilitate improved treatment methods for comorbid disease and drug dependence." @default.
- W2078343399 created "2016-06-24" @default.
- W2078343399 creator A5028559117 @default.
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- W2078343399 creator A5062608103 @default.
- W2078343399 creator A5084863204 @default.
- W2078343399 date "2013-01-01" @default.
- W2078343399 modified "2023-09-24" @default.
- W2078343399 title "Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice" @default.
- W2078343399 cites W1546717961 @default.
- W2078343399 cites W1581091695 @default.
- W2078343399 cites W1829678825 @default.
- W2078343399 cites W1900874372 @default.
- W2078343399 cites W1916878534 @default.
- W2078343399 cites W1966544510 @default.
- W2078343399 cites W1967005816 @default.
- W2078343399 cites W1968534751 @default.
- W2078343399 cites W1976434061 @default.
- W2078343399 cites W1977517471 @default.
- W2078343399 cites W1978090608 @default.
- W2078343399 cites W1979339518 @default.
- W2078343399 cites W1984107995 @default.
- W2078343399 cites W1984482648 @default.
- W2078343399 cites W1987224349 @default.
- W2078343399 cites W1991094289 @default.
- W2078343399 cites W1995324729 @default.
- W2078343399 cites W1995510372 @default.
- W2078343399 cites W1995751463 @default.
- W2078343399 cites W1997303573 @default.
- W2078343399 cites W1997596082 @default.
- W2078343399 cites W1999071682 @default.
- W2078343399 cites W2003074165 @default.
- W2078343399 cites W2006855887 @default.
- W2078343399 cites W2009006904 @default.
- W2078343399 cites W2012947665 @default.
- W2078343399 cites W2016836786 @default.
- W2078343399 cites W2017111165 @default.
- W2078343399 cites W2017387524 @default.
- W2078343399 cites W2018418890 @default.
- W2078343399 cites W2020586880 @default.
- W2078343399 cites W2020914845 @default.
- W2078343399 cites W2021338883 @default.
- W2078343399 cites W2022056804 @default.
- W2078343399 cites W2022406556 @default.
- W2078343399 cites W2023803162 @default.
- W2078343399 cites W2027885912 @default.
- W2078343399 cites W2030949461 @default.
- W2078343399 cites W2032498966 @default.
- W2078343399 cites W2034922281 @default.
- W2078343399 cites W2036344982 @default.
- W2078343399 cites W2037968607 @default.
- W2078343399 cites W2039734715 @default.
- W2078343399 cites W2042441113 @default.
- W2078343399 cites W2045304025 @default.
- W2078343399 cites W2046346645 @default.
- W2078343399 cites W2048380200 @default.
- W2078343399 cites W2053486952 @default.
- W2078343399 cites W2054091091 @default.
- W2078343399 cites W2058972512 @default.
- W2078343399 cites W2064085644 @default.
- W2078343399 cites W2066680759 @default.
- W2078343399 cites W2067550112 @default.
- W2078343399 cites W2068608123 @default.
- W2078343399 cites W2080407003 @default.
- W2078343399 cites W2083131011 @default.
- W2078343399 cites W2087878285 @default.
- W2078343399 cites W2091073665 @default.
- W2078343399 cites W2091388219 @default.
- W2078343399 cites W2093002459 @default.
- W2078343399 cites W2093530590 @default.
- W2078343399 cites W2097667540 @default.
- W2078343399 cites W2106287416 @default.
- W2078343399 cites W2109995245 @default.
- W2078343399 cites W2114775664 @default.
- W2078343399 cites W2117093911 @default.
- W2078343399 cites W2117390254 @default.
- W2078343399 cites W2118335987 @default.
- W2078343399 cites W2126463954 @default.
- W2078343399 cites W2126608268 @default.
- W2078343399 cites W2138902434 @default.
- W2078343399 cites W2144884422 @default.
- W2078343399 cites W2144902190 @default.
- W2078343399 cites W2154308586 @default.
- W2078343399 cites W2157188734 @default.
- W2078343399 cites W2159442897 @default.
- W2078343399 cites W2159740301 @default.
- W2078343399 cites W4255453259 @default.
- W2078343399 doi "https://doi.org/10.1016/j.bbr.2012.08.037" @default.
- W2078343399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3482284" @default.
- W2078343399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22960458" @default.
- W2078343399 hasPublicationYear "2013" @default.
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