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- W2078347537 abstract "Amantadine and dopamine have been applied by microiontophoresis to single neurones in the cerebral cortex. While the dopamine receptor blocker alpha-flupenthixol antagonized responses to dopamine, it only partially reduced responses to amantadine. The effects of alpha-flupenthixol on dopamine and amantadine responses were highly significantly different (P < 0.001). Amantadine was probably not acting on noradrenaline receptors since it was unaffected by propranolol. Thus, amantadine may have a non-catecholaminergic action, which may explain the previously noted inability of catecholamine depletion to prevent the effects of the drug." @default.
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- W2078347537 date "1977-05-01" @default.
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- W2078347537 title "Evidence for a non-dopaminergic action of amantadine" @default.
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- W2078347537 doi "https://doi.org/10.1016/0304-3940(77)90181-1" @default.
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