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- W2078348074 abstract "Normal heart formation requires reiterative phases of canonical Wnt/β-catenin (Wnt) signaling. Understanding the mechanisms by which Wnt signaling directs cardiomyocyte (CM) formation in vivo is critical to being able to precisely direct differentiated CMs from stem cells in vitro. Here, we investigate the roles of Wnt signaling in zebrafish CM formation using heat-shock inducible transgenes that increase and decrease Wnt signaling. We find that there are three phases during which CM formation is sensitive to modulation of Wnt signaling through the first 24 h of development. In addition to the previously recognized roles for Wnt signaling during mesoderm specification and in the pre-cardiac mesoderm, we find a previously unrecognized role during CM differentiation where Wnt signaling is necessary and sufficient to promote the differentiation of additional atrial cells. We also extend the previous studies of the roles of Wnt signaling during mesoderm specification and in pre-cardiac mesoderm. Importantly, in pre-cardiac mesoderm we define a new mechanism where Wnt signaling is sufficient to prevent CM differentiation, in contrast to a proposed role in inhibiting cardiac progenitor (CP) specification. The inability of the CPs to differentiate appears to lead to cell death through a p53/Caspase-3 independent mechanism. Together with a report for an even later role for Wnt signaling in restricting proliferation of differentiated ventricular CMs, our results indicate that during the first 3 days of development in zebrafish there are four distinct phases during which CMs are sensitive to Wnt signaling." @default.
- W2078348074 created "2016-06-24" @default.
- W2078348074 creator A5089357296 @default.
- W2078348074 creator A5091779911 @default.
- W2078348074 date "2012-01-01" @default.
- W2078348074 modified "2023-10-16" @default.
- W2078348074 title "Distinct phases of Wnt/β-catenin signaling direct cardiomyocyte formation in zebrafish" @default.
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- W2078348074 doi "https://doi.org/10.1016/j.ydbio.2011.10.032" @default.
- W2078348074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246556" @default.
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- W2078348074 hasPublicationYear "2012" @default.
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