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- W2078349853 abstract "In the pharmacological treatment of dementia of the Alzheimer's type (DAT), patient and caregiver preferences are essential to the assessment of clinical meaningfulness. Goal Attainment Scaling (GAtS) formally evaluates these expectations. The technique measures outcomes by an approach that is standardized in its analysis but individualized for each subject. GAtS has been employed in studies of geriatric subjects in various settings including the community, nursing homes, after discharge from a day hospital, and in pharmacological intervention studies. To date, there have been no large-scale evaluations of goal attainment in moderate-to-severe DAT in any region. Thus, there is sparse information on types of goals able to be set by patients, whether factors such as gender of caregiver impact goal setting and whether there are regional differences in goals. These and other factors may be important not only in establishing the clinical meaningfulness of the results of a trial, but may play an important role in study design of future clinical trials. From a large 24 week, double-blind, parallel group study of donepezil vs. placebo, data will be presented on goals set at baseline by up to 1600 caregivers and patients with moderate to severe DAT (MMSE 1–20). The study is global, with over 200 sites across North America, South America, Europe, Asia, Oceania and South Africa. At study initiation the caregiver and patient are separately asked to specify up to four goals. First, dementia-related symptoms in which improvement is desired are defined. These are then defined in plain language, and plausibly better and worse states are established and recorded. The resulting scale, scored from 0 at baseline, ranges from +2 (“much better” [than baseline])” to -2 (“much worse”). The analyses from this large, unique, global dataset will include: proportions of patients per MMSE grouping who are able to define and set goals at baseline; concordance between caregiver and patient-set goals; influence on caregiver goal of caregiver gender and MMSE of the patient. The results may have the potential for better understanding of the expectations of patients and their caregivers from pharmacological intervention in moderate to severe DAT." @default.
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- W2078349853 date "2008-07-01" @default.
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- W2078349853 title "P3-461: Goal attainment in dementia of the Alzheimer's type in a study of moderate to severe cognitive impairment" @default.
- W2078349853 doi "https://doi.org/10.1016/j.jalz.2008.05.2032" @default.
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