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- W2078351698 abstract "The 12-item Neuropathic Pain Questionnaire (NPQ) was developed to differentiate neuropathic from non-neuropathic pain and may be used for monitoring treatment1. NGX-4010 is a capsaicin 8% patch indicated for the management of postherpetic neuralgia (PHN). Patients rated each NPQ item on a 0-100 scale at screening and week 12 in addition to daily recording of “average pain for the past 24 hours” Numeric Pain Rating Scale (NPRS) score. Integrated data from 385 patients who received a single, 1-hour, localized NGX-4010 treatment and 326 patients who received a single 30-, 60- or 90-minute 0.04% capsaicin control patch application showed that the mean percentage change from baseline to Weeks 2–12 in “average pain for the past 24 hours” NPRS score was -30.8% in NGX-4010-treated patients compared to -21.1% in controls (p<0.0001). At week 12, NGX-4010-treated patients experienced more reduction from screening on all NPQ items compared to controls but only in patients with burning pain, shooting pain or numbness were these reductions significantly different. At screening, 81% and 82% of NGX-4010-treated and control patients, respectively, had burning pain, 70% and 77%, respectively, had shooting pain, and 46% and 45%, respectively, had numbness. At week 12, median percent reduction from baseline in burning pain was 40% in NGX-4010-treated patients compared to 27% in controls (p=0.0046); about 29% of NGX-4010-treated patients achieved complete resolution. Median percent reduction from baseline in shooting pain was 50% in NGX-4010-treated patients compared to 29% in controls (p=0.0124); about 30% of NGX-4010-treated patients achieved complete resolution. Median percent reduction from baseline in numbness was 54% in NGX-4010-treated patients compared to 33% in controls (p=0.0147); about 33% NGX-4010-treated patients achieved complete resolution. These results show that NGX-4010 can provide 3 months of PHN relief, providing the largest degree of relief for burning pain, shooting pain or numbness." @default.
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- W2078351698 date "2011-04-01" @default.
- W2078351698 modified "2023-09-25" @default.
- W2078351698 title "The effect of NGX-4010, a prescription strength capsaicin 8% patch, on the Neuropathic Pain Questionnaire in patients with postherpetic neuralgia" @default.
- W2078351698 doi "https://doi.org/10.1016/j.jpain.2011.02.016" @default.
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