Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078352855> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2078352855 endingPage "430" @default.
- W2078352855 startingPage "425" @default.
- W2078352855 abstract "Abstract Effects of a subacute dose (150 mg/kg body wt) of methionine sulfoximine was studied on the behavioural changes and glutamine synthetase activity in cerebral cortex, cerebellum and brain stem of rats of four different age groups. Animals of 10 days and 90 days age groups were less vulnerable to the toxic effects of methionine sulfoximine. Rats of 180 days age exhibited various behavioural changes upon the administration of methionine sulfoximine and entered into convulsions at the end of 17 hr. In rats of 360 days age group these changes appeared quite early and the animals convulsed at the end of 13 hr. Animals of these two age groups failed to recover from toxic effects of methionine sulfoximine. Methionine sulfoximine inhibited glutamine synthetase activity in the brains of rats of all age groups. Maximum inhibition of activity was noticed at the end of 12 hr in 10‐day‐old rats while in the animals of other age groups it was seen at the end of 3 hr. In animals of all age groups the enzyme activity was inhibited by 60–70% except in 360‐day‐old rats where the inhibition was 95%. Behavioural changes and inhibition of glutamine synthetase were out of phase with each other. It is suggested that the toxicity of methionine sulfoximine may not be due to its effect on glutamine synthetase alone. Further, these results also suggest that the toxic effects of methionine sulfoximine vary with the age of the animal." @default.
- W2078352855 created "2016-06-24" @default.
- W2078352855 creator A5064816567 @default.
- W2078352855 creator A5087453054 @default.
- W2078352855 date "1988-01-01" @default.
- W2078352855 modified "2023-10-18" @default.
- W2078352855 title "Age‐dependent variation in the sensitivity of rat brain glutamine synthetase to <scp>l</scp>‐methionine‐<scp>dl</scp>‐sulfoximine" @default.
- W2078352855 cites W1423235038 @default.
- W2078352855 cites W1509276235 @default.
- W2078352855 cites W1974568706 @default.
- W2078352855 cites W1975014910 @default.
- W2078352855 cites W1976531271 @default.
- W2078352855 cites W1980573610 @default.
- W2078352855 cites W1987080089 @default.
- W2078352855 cites W2003929979 @default.
- W2078352855 cites W2010471690 @default.
- W2078352855 cites W202004645 @default.
- W2078352855 cites W2043803739 @default.
- W2078352855 cites W2056574644 @default.
- W2078352855 cites W2056591145 @default.
- W2078352855 cites W2065373599 @default.
- W2078352855 cites W2076315698 @default.
- W2078352855 cites W2136126428 @default.
- W2078352855 cites W2410085894 @default.
- W2078352855 cites W64722124 @default.
- W2078352855 doi "https://doi.org/10.1016/0736-5748(88)90048-2" @default.
- W2078352855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2904726" @default.
- W2078352855 hasPublicationYear "1988" @default.
- W2078352855 type Work @default.
- W2078352855 sameAs 2078352855 @default.
- W2078352855 citedByCount "8" @default.
- W2078352855 crossrefType "journal-article" @default.
- W2078352855 hasAuthorship W2078352855A5064816567 @default.
- W2078352855 hasAuthorship W2078352855A5087453054 @default.
- W2078352855 hasConcept C126322002 @default.
- W2078352855 hasConcept C134018914 @default.
- W2078352855 hasConcept C181199279 @default.
- W2078352855 hasConcept C185592680 @default.
- W2078352855 hasConcept C2779289688 @default.
- W2078352855 hasConcept C2779349466 @default.
- W2078352855 hasConcept C2779652256 @default.
- W2078352855 hasConcept C2780912031 @default.
- W2078352855 hasConcept C29730261 @default.
- W2078352855 hasConcept C515207424 @default.
- W2078352855 hasConcept C55493867 @default.
- W2078352855 hasConcept C71924100 @default.
- W2078352855 hasConcept C86803240 @default.
- W2078352855 hasConceptScore W2078352855C126322002 @default.
- W2078352855 hasConceptScore W2078352855C134018914 @default.
- W2078352855 hasConceptScore W2078352855C181199279 @default.
- W2078352855 hasConceptScore W2078352855C185592680 @default.
- W2078352855 hasConceptScore W2078352855C2779289688 @default.
- W2078352855 hasConceptScore W2078352855C2779349466 @default.
- W2078352855 hasConceptScore W2078352855C2779652256 @default.
- W2078352855 hasConceptScore W2078352855C2780912031 @default.
- W2078352855 hasConceptScore W2078352855C29730261 @default.
- W2078352855 hasConceptScore W2078352855C515207424 @default.
- W2078352855 hasConceptScore W2078352855C55493867 @default.
- W2078352855 hasConceptScore W2078352855C71924100 @default.
- W2078352855 hasConceptScore W2078352855C86803240 @default.
- W2078352855 hasIssue "5" @default.
- W2078352855 hasLocation W20783528551 @default.
- W2078352855 hasLocation W20783528552 @default.
- W2078352855 hasOpenAccess W2078352855 @default.
- W2078352855 hasPrimaryLocation W20783528551 @default.
- W2078352855 hasRelatedWork W1569063200 @default.
- W2078352855 hasRelatedWork W1866222897 @default.
- W2078352855 hasRelatedWork W2016733795 @default.
- W2078352855 hasRelatedWork W2022749662 @default.
- W2078352855 hasRelatedWork W2029624447 @default.
- W2078352855 hasRelatedWork W2060794300 @default.
- W2078352855 hasRelatedWork W2081780014 @default.
- W2078352855 hasRelatedWork W2094643509 @default.
- W2078352855 hasRelatedWork W2111784969 @default.
- W2078352855 hasRelatedWork W2119738915 @default.
- W2078352855 hasVolume "6" @default.
- W2078352855 isParatext "false" @default.
- W2078352855 isRetracted "false" @default.
- W2078352855 magId "2078352855" @default.
- W2078352855 workType "article" @default.