Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078353225> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2078353225 endingPage "421" @default.
- W2078353225 startingPage "419" @default.
- W2078353225 abstract "Abstract Cytochrome P450 (CYP) enzymes are responsible for much of the phase I oxidative metabolism observed in vivo . Many important pharmaceutical compounds are metabolized by CYP. Co‐administration of a drug with another agent can alter the efficacy or the toxicity, especially in cases where drug clearance depends primarily on the CYP metabolism. Compounds that induce or inhibit the CYP activity are often used in drug–drug interaction studies. Midazolam is one such compound that is routinely used in drug–drug interaction studies because it is a known substrate for CYP3A enzymes. The synthesis of this important tool molecule has been documented, but unfortunately a detailed preparation of carbon‐14‐labelled midazolam has not been reported in the literature. This paper describes a two‐step synthesis leading to [ 14 C]midazolam. A total of 4.5 mCi of [ 14 C]midazolam was obtained having a specific activity of 120.1 µCi/mg (39.12 mCi/mmol). The radiochemical purity as determined by HPLC was 99.8% and the overall radiochemical yield was 9%. Copyright © 2009 John Wiley & Sons, Ltd." @default.
- W2078353225 created "2016-06-24" @default.
- W2078353225 creator A5050610121 @default.
- W2078353225 creator A5077107850 @default.
- W2078353225 creator A5080510424 @default.
- W2078353225 creator A5085626015 @default.
- W2078353225 date "2009-07-03" @default.
- W2078353225 modified "2023-10-18" @default.
- W2078353225 title "Synthesis of carbon-14 labelled midazolam" @default.
- W2078353225 cites W1971559706 @default.
- W2078353225 cites W1978602437 @default.
- W2078353225 cites W1983855718 @default.
- W2078353225 cites W2005840286 @default.
- W2078353225 cites W2012712901 @default.
- W2078353225 cites W2027608292 @default.
- W2078353225 cites W2056431923 @default.
- W2078353225 cites W2082622493 @default.
- W2078353225 cites W2136756293 @default.
- W2078353225 cites W2163536623 @default.
- W2078353225 doi "https://doi.org/10.1002/jlcr.1620" @default.
- W2078353225 hasPublicationYear "2009" @default.
- W2078353225 type Work @default.
- W2078353225 sameAs 2078353225 @default.
- W2078353225 citedByCount "3" @default.
- W2078353225 countsByYear W20783532252015 @default.
- W2078353225 countsByYear W20783532252017 @default.
- W2078353225 crossrefType "journal-article" @default.
- W2078353225 hasAuthorship W2078353225A5050610121 @default.
- W2078353225 hasAuthorship W2078353225A5077107850 @default.
- W2078353225 hasAuthorship W2078353225A5080510424 @default.
- W2078353225 hasAuthorship W2078353225A5085626015 @default.
- W2078353225 hasConcept C111368507 @default.
- W2078353225 hasConcept C11824378 @default.
- W2078353225 hasConcept C127313418 @default.
- W2078353225 hasConcept C150903083 @default.
- W2078353225 hasConcept C181199279 @default.
- W2078353225 hasConcept C185592680 @default.
- W2078353225 hasConcept C207001950 @default.
- W2078353225 hasConcept C2776814716 @default.
- W2078353225 hasConcept C2777289219 @default.
- W2078353225 hasConcept C2778000748 @default.
- W2078353225 hasConcept C2780035454 @default.
- W2078353225 hasConcept C526171541 @default.
- W2078353225 hasConcept C55493867 @default.
- W2078353225 hasConcept C62231903 @default.
- W2078353225 hasConcept C71924100 @default.
- W2078353225 hasConcept C86803240 @default.
- W2078353225 hasConcept C89311334 @default.
- W2078353225 hasConcept C98274493 @default.
- W2078353225 hasConceptScore W2078353225C111368507 @default.
- W2078353225 hasConceptScore W2078353225C11824378 @default.
- W2078353225 hasConceptScore W2078353225C127313418 @default.
- W2078353225 hasConceptScore W2078353225C150903083 @default.
- W2078353225 hasConceptScore W2078353225C181199279 @default.
- W2078353225 hasConceptScore W2078353225C185592680 @default.
- W2078353225 hasConceptScore W2078353225C207001950 @default.
- W2078353225 hasConceptScore W2078353225C2776814716 @default.
- W2078353225 hasConceptScore W2078353225C2777289219 @default.
- W2078353225 hasConceptScore W2078353225C2778000748 @default.
- W2078353225 hasConceptScore W2078353225C2780035454 @default.
- W2078353225 hasConceptScore W2078353225C526171541 @default.
- W2078353225 hasConceptScore W2078353225C55493867 @default.
- W2078353225 hasConceptScore W2078353225C62231903 @default.
- W2078353225 hasConceptScore W2078353225C71924100 @default.
- W2078353225 hasConceptScore W2078353225C86803240 @default.
- W2078353225 hasConceptScore W2078353225C89311334 @default.
- W2078353225 hasConceptScore W2078353225C98274493 @default.
- W2078353225 hasIssue "10" @default.
- W2078353225 hasLocation W20783532251 @default.
- W2078353225 hasOpenAccess W2078353225 @default.
- W2078353225 hasPrimaryLocation W20783532251 @default.
- W2078353225 hasRelatedWork W1817672374 @default.
- W2078353225 hasRelatedWork W2021847316 @default.
- W2078353225 hasRelatedWork W2043717583 @default.
- W2078353225 hasRelatedWork W2054911076 @default.
- W2078353225 hasRelatedWork W2058695256 @default.
- W2078353225 hasRelatedWork W2073679765 @default.
- W2078353225 hasRelatedWork W2109737906 @default.
- W2078353225 hasRelatedWork W2114089215 @default.
- W2078353225 hasRelatedWork W2372482745 @default.
- W2078353225 hasRelatedWork W2786932006 @default.
- W2078353225 hasVolume "52" @default.
- W2078353225 isParatext "false" @default.
- W2078353225 isRetracted "false" @default.
- W2078353225 magId "2078353225" @default.
- W2078353225 workType "article" @default.