Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078353587> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2078353587 endingPage "1940" @default.
- W2078353587 startingPage "1932" @default.
- W2078353587 abstract "Abstract: We have found earlier that the neuromuscular blocker alcuronium binds to cardiac muscarinic receptors simultaneously with their specific antagonist [3H]methyl-N-scopolamine ([3H]NMS) and allosterically increases their affinity to this ligand. Nothing is known about the allosteric site with which alcuronium interacts. To gain an insight, we have now investigated how the binding of [3H]NMS is affected by agents known to modify specific residues in proteins and how their effects are altered by alcuronium. Reagents that covalently modify the tyrosyl residues (p-nitrobenzenesulfonyl fluoride and 4-chloro-7-nitrobenzofurazan) and the carboxyl groups of aspartate and glutamate [1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N,N′-dicyclohexylcarbodiimide, and N-ethyl-5-phenylisoxazolium-3′-sulfonate] blocked the binding of [3H]NMS to receptors in rat heart atria. Their action was probably due to the modification of tyrosyl and aspartyl residues directly in the muscarinic binding sites because it was antagonized by atropine and carbamoylcholine. Alcuronium and gallamine, another allosteric ligand, also protected the [3H]NMS binding sites against the inactivation by tyrosine- and carboxyl-directed chemical modifiers just as well as by benzilylcholine mustard, known to attach covalently to the muscarinic binding sites. Protection by alcuronium has also been observed on cerebrocortical muscarinic receptors. The effect of alcuronium indicates that the drug interferes with the access of chemical modifiers to the muscarinic sites. In view of the unspecific nature of most of the modifiers used (with regard to muscarinic mechanisms), the protection by alcuronium appears to be best explained on the assumption that the drug binds in close vicinity of the “classical” muscarinic site and sterically blocks the access to this site." @default.
- W2078353587 created "2016-06-24" @default.
- W2078353587 creator A5048482070 @default.
- W2078353587 creator A5064762001 @default.
- W2078353587 date "2002-11-23" @default.
- W2078353587 modified "2023-10-08" @default.
- W2078353587 title "Protection by Alcuronium of Muscarinic Receptors Against Chemical Inactivation and Location of the Allosteric Binding Site for Alcuronium" @default.
- W2078353587 doi "https://doi.org/10.1046/j.1471-4159.1994.63051932.x" @default.
- W2078353587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7931349" @default.
- W2078353587 hasPublicationYear "2002" @default.
- W2078353587 type Work @default.
- W2078353587 sameAs 2078353587 @default.
- W2078353587 citedByCount "26" @default.
- W2078353587 countsByYear W20783535872016 @default.
- W2078353587 crossrefType "journal-article" @default.
- W2078353587 hasAuthorship W2078353587A5048482070 @default.
- W2078353587 hasAuthorship W2078353587A5064762001 @default.
- W2078353587 hasConcept C107824862 @default.
- W2078353587 hasConcept C116569031 @default.
- W2078353587 hasConcept C166342909 @default.
- W2078353587 hasConcept C170493617 @default.
- W2078353587 hasConcept C185592680 @default.
- W2078353587 hasConcept C33789571 @default.
- W2078353587 hasConcept C47488739 @default.
- W2078353587 hasConcept C55493867 @default.
- W2078353587 hasConcept C71240020 @default.
- W2078353587 hasConcept C86803240 @default.
- W2078353587 hasConcept C98274493 @default.
- W2078353587 hasConceptScore W2078353587C107824862 @default.
- W2078353587 hasConceptScore W2078353587C116569031 @default.
- W2078353587 hasConceptScore W2078353587C166342909 @default.
- W2078353587 hasConceptScore W2078353587C170493617 @default.
- W2078353587 hasConceptScore W2078353587C185592680 @default.
- W2078353587 hasConceptScore W2078353587C33789571 @default.
- W2078353587 hasConceptScore W2078353587C47488739 @default.
- W2078353587 hasConceptScore W2078353587C55493867 @default.
- W2078353587 hasConceptScore W2078353587C71240020 @default.
- W2078353587 hasConceptScore W2078353587C86803240 @default.
- W2078353587 hasConceptScore W2078353587C98274493 @default.
- W2078353587 hasIssue "5" @default.
- W2078353587 hasLocation W20783535871 @default.
- W2078353587 hasLocation W20783535872 @default.
- W2078353587 hasOpenAccess W2078353587 @default.
- W2078353587 hasPrimaryLocation W20783535871 @default.
- W2078353587 hasRelatedWork W1991459633 @default.
- W2078353587 hasRelatedWork W2009115494 @default.
- W2078353587 hasRelatedWork W2049709060 @default.
- W2078353587 hasRelatedWork W2105273978 @default.
- W2078353587 hasRelatedWork W2171389375 @default.
- W2078353587 hasRelatedWork W2415257862 @default.
- W2078353587 hasRelatedWork W2415423152 @default.
- W2078353587 hasRelatedWork W2574507094 @default.
- W2078353587 hasRelatedWork W2604806264 @default.
- W2078353587 hasRelatedWork W2950751697 @default.
- W2078353587 hasVolume "63" @default.
- W2078353587 isParatext "false" @default.
- W2078353587 isRetracted "false" @default.
- W2078353587 magId "2078353587" @default.
- W2078353587 workType "article" @default.