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• W2078356972 abstract "B cells of varying antigen specificities are consistently present in the unmanipulated repertoire. These B cells appear to belong to the marginal zone (MZ) and B1 B-cell subsets and provide protection to the blood and lymph, respectively. Some are specific for self-antigens, suggesting that they are selected based on specificity for self but have a protective role against foreign pathogens. One of these specificities is for phosphatidylcholine (PtC). Anti-PtC B cells comprise 5-8% of the B1 repertoire and are protective against bacterial pathogens. In general, they are restricted to the expression of two VH/Vkappa combinations, VH11/Vkappa9 and VH12/Vkappa4/5H. This review focuses on the differentiation of VH12 anti-PtC B cells. They undergo a series of positive selection events beginning at the pre-B-cell stage that enriches for those with a VHCDR3 and L chain required for PtC binding and eliminating the majority of VH12 B cells that lack the ability to bind PtC. Thus, positive selection focuses the VH12 repertoire toward PtC, ensuring that anti-PtC VH12 B cells are a significant component of the B1-cell repertoire in all individuals." @default.
• W2078356972 created "2016-06-24" @default.
• W2078356972 creator A5047090777 @default.
• W2078356972 creator A5085233592 @default.
• W2078356972 date "2004-01-06" @default.
• W2078356972 modified "2023-10-17" @default.
• W2078356972 title "Positive selection focuses the V_H12 B‐cell repertoire towards a single B1 specificity with survival function" @default.
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• W2078356972 doi "https://doi.org/10.1111/j.0105-2896.2004.0098.x" @default.
• W2078356972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14962186" @default.
• W2078356972 hasPublicationYear "2004" @default.
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