FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078357707> ?p ?o ?g. }

• W2078357707 endingPage "1749" @default.
• W2078357707 startingPage "1745" @default.
• W2078357707 abstract "Objectives To analyze whether complement C3a anaphylatoxin, other C3 fragments, interleukin-1β (IL-1β), or tumor necrosis factor-α (TNF-α) contributes to inflammation in chronic otitis media with effusion (OME). Methods The amount of C3a was measured by enzyme-linked immunoassay. Further breakdown of C3 was analyzed by Western blotting. IL-1β and TNF-α concentrations were measured by radioimmunoassay. Bacteria were analyzed by culture and polymerase chain reaction. Results Highly elevated levels of C3a and other C3 cleavage fragments were found in all middle ear effusion (MEE) samples. The mean values (± SEM, n = 26) for C3a, IL-1β, and TNF-α were 5973 ± 1124 ng/mL, 1043 ± 490 pg/mL, and 79 ± 14.3 pg/mL, respectively. Comparison to an average C3 level of 555 (±108) μg/mL indicated that at least 40.5% ± 6% of total C3 had become activated within the MEE. C3a concentrations were higher in the group in which the effusion had been present in the middle ear for a prolonged period (≥4 mo) (P = .04). Children with multiple tube insertions had higher C3 (P = .006) and TNF-α (P = .04) concentrations in their MEE samples than those receiving their first tubes. C3 and C3a concentrations in MEE correlated to each other (correlation coefficient [r] = 0.513, P = .0056), as did concentrations of IL-1β and TNF-α (r = 0.7016, P < .0001). No significant correlation was found between complement C3 or C3a levels and IL-1β, TNF-α, or bacterial growth. Conclusions Highly elevated levels of C3a in MEE indicate ongoing complement activation, which is stronger than in almost any other disease demonstrated previously. Elevated C3a levels contribute to chemotactic and inflammatory potential in the MEE and correlate with the chronicity of the disease." @default.
• W2078357707 created "2016-06-24" @default.
• W2078357707 creator A5025820462 @default.
• W2078357707 creator A5033908778 @default.
• W2078357707 creator A5074166450 @default.
• W2078357707 date "2000-10-01" @default.
• W2078357707 modified "2023-09-27" @default.
• W2078357707 title "Complement C3 Cleavage and Cytokines Interleukin-1?? and Tumor Necrosis Factor-?? in Otitis Media With Effusion" @default.
• W2078357707 cites W136269263 @default.
• W2078357707 cites W1832124212 @default.
• W2078357707 cites W1963135944 @default.
• W2078357707 cites W1988653399 @default.
• W2078357707 cites W2005858585 @default.
• W2078357707 cites W2038646932 @default.
• W2078357707 cites W2049071821 @default.
• W2078357707 cites W2054946013 @default.
• W2078357707 cites W2055508283 @default.
• W2078357707 cites W2066192340 @default.
• W2078357707 cites W2079108237 @default.
• W2078357707 cites W2112249032 @default.
• W2078357707 cites W2120162013 @default.
• W2078357707 cites W2125221360 @default.
• W2078357707 cites W2132426657 @default.
• W2078357707 doi "https://doi.org/10.1097/00005537-200010000-00035" @default.
• W2078357707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11037838" @default.
• W2078357707 hasPublicationYear "2000" @default.
• W2078357707 type Work @default.
• W2078357707 sameAs 2078357707 @default.
• W2078357707 citedByCount "25" @default.
• W2078357707 countsByYear W20783577072013 @default.
• W2078357707 countsByYear W20783577072014 @default.
• W2078357707 countsByYear W20783577072021 @default.
• W2078357707 countsByYear W20783577072022 @default.
• W2078357707 crossrefType "journal-article" @default.
• W2078357707 hasAuthorship W2078357707A5025820462 @default.
• W2078357707 hasAuthorship W2078357707A5033908778 @default.
• W2078357707 hasAuthorship W2078357707A5074166450 @default.
• W2078357707 hasConcept C111684460 @default.
• W2078357707 hasConcept C126322002 @default.
• W2078357707 hasConcept C134018914 @default.
• W2078357707 hasConcept C141071460 @default.
• W2078357707 hasConcept C153911025 @default.
• W2078357707 hasConcept C163430725 @default.
• W2078357707 hasConcept C176685330 @default.
• W2078357707 hasConcept C17991360 @default.
• W2078357707 hasConcept C203014093 @default.
• W2078357707 hasConcept C2776439223 @default.
• W2078357707 hasConcept C2778690821 @default.
• W2078357707 hasConcept C71924100 @default.
• W2078357707 hasConcept C74172505 @default.
• W2078357707 hasConcept C86803240 @default.
• W2078357707 hasConcept C8891405 @default.
• W2078357707 hasConcept C90582226 @default.
• W2078357707 hasConceptScore W2078357707C111684460 @default.
• W2078357707 hasConceptScore W2078357707C126322002 @default.
• W2078357707 hasConceptScore W2078357707C134018914 @default.
• W2078357707 hasConceptScore W2078357707C141071460 @default.
• W2078357707 hasConceptScore W2078357707C153911025 @default.
• W2078357707 hasConceptScore W2078357707C163430725 @default.
• W2078357707 hasConceptScore W2078357707C176685330 @default.
• W2078357707 hasConceptScore W2078357707C17991360 @default.
• W2078357707 hasConceptScore W2078357707C203014093 @default.
• W2078357707 hasConceptScore W2078357707C2776439223 @default.
• W2078357707 hasConceptScore W2078357707C2778690821 @default.
• W2078357707 hasConceptScore W2078357707C71924100 @default.
• W2078357707 hasConceptScore W2078357707C74172505 @default.
• W2078357707 hasConceptScore W2078357707C86803240 @default.
• W2078357707 hasConceptScore W2078357707C8891405 @default.
• W2078357707 hasConceptScore W2078357707C90582226 @default.
• W2078357707 hasIssue "10" @default.
• W2078357707 hasLocation W20783577071 @default.
• W2078357707 hasLocation W20783577072 @default.
• W2078357707 hasOpenAccess W2078357707 @default.
• W2078357707 hasPrimaryLocation W20783577071 @default.
• W2078357707 hasRelatedWork W1970951606 @default.
• W2078357707 hasRelatedWork W1980760188 @default.
• W2078357707 hasRelatedWork W1988653399 @default.
• W2078357707 hasRelatedWork W2006549602 @default.
• W2078357707 hasRelatedWork W2022069977 @default.
• W2078357707 hasRelatedWork W2033943476 @default.
• W2078357707 hasRelatedWork W2058293508 @default.
• W2078357707 hasRelatedWork W2078357707 @default.
• W2078357707 hasRelatedWork W2080767539 @default.
• W2078357707 hasRelatedWork W2125221360 @default.
• W2078357707 hasVolume "110" @default.
• W2078357707 isParatext "false" @default.
• W2078357707 isRetracted "false" @default.
• W2078357707 magId "2078357707" @default.
• W2078357707 workType "article" @default.