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• W2078360530 abstract "Abstract CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53+/− mice lacking either type I NKT cells (TCR Jα18−/−) or all CD1d-restricted T cells (CD1d−/−). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development." @default.
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• W2078360530 date "2009-06-18" @default.
• W2078360530 modified "2023-09-26" @default.
• W2078360530 title "Type I natural killer T cells suppress tumors caused by p53 loss in mice" @default.
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• W2078360530 doi "https://doi.org/10.1182/blood-2009-01-198564" @default.
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