FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078361523> ?p ?o ?g. }

• W2078361523 endingPage "461" @default.
• W2078361523 startingPage "455" @default.
• W2078361523 abstract "Recent work has suggested that environmental enrichment during development can enhance aspects of learning and memory, however its effects on executive function and cognitive flexibility have not been well studied. The goal of this research was to evaluate whether environmental enrichment (EE) that included wheel running would improve cognitive performance in young male Long Evans rats that received subchronic administration of either phencyclidine (PCP) or saline. We used a sensitive extradimensional/intradimensional (ED/ID) test of cognitive flexibility similar to that used in humans and nonhuman primates for assessing executive function. PCP-treated rats demonstrated a selective impairment on ED shift (EDS) performance without significant impairment on other discrimination problems when compared to saline treated control animals. A separate group of animals that received PCP + EE demonstrated significantly improved performance on EDS and reversal learning problems, whereas the saline + EE group demonstrated a non-selective improvement in overall performance when compared to non-enriched saline controls. The saline + EE group demonstrated greater activity levels as measured by wheel running when compared to the PCP + EE group, but no significant associations were found between wheel running and cognitive performance. Together, these data suggest that EE that features wheel running may have promoted a general cognitive enhancement while also selectively acting upon neurobiological mechanisms that subserve executive function and cognitive flexibility in impaired animals. Development of novel treatment methodologies that target mechanisms underlying the ameliorative effects of EE in this model of cognitive impairment may be a useful tool in the development of new therapeutic strategies for disorders that feature cognitive dysfunction as a key symptom." @default.
• W2078361523 created "2016-06-24" @default.
• W2078361523 creator A5001237444 @default.
• W2078361523 creator A5090466401 @default.
• W2078361523 date "2011-05-01" @default.
• W2078361523 modified "2023-10-14" @default.
• W2078361523 title "Environmental enrichment ameliorates phencyclidine-induced cognitive deficits" @default.
• W2078361523 cites W1481984979 @default.
• W2078361523 cites W1505976679 @default.
• W2078361523 cites W1616286551 @default.
• W2078361523 cites W1821906452 @default.
• W2078361523 cites W1964359453 @default.
• W2078361523 cites W1980542913 @default.
• W2078361523 cites W1980590920 @default.
• W2078361523 cites W1984612389 @default.
• W2078361523 cites W1986459770 @default.
• W2078361523 cites W1987412250 @default.
• W2078361523 cites W1987520942 @default.
• W2078361523 cites W1990121428 @default.
• W2078361523 cites W1992179353 @default.
• W2078361523 cites W1993018409 @default.
• W2078361523 cites W1996598982 @default.
• W2078361523 cites W2003977784 @default.
• W2078361523 cites W2005972779 @default.
• W2078361523 cites W2007709475 @default.
• W2078361523 cites W2007816528 @default.
• W2078361523 cites W2020924958 @default.
• W2078361523 cites W2024868884 @default.
• W2078361523 cites W2043922259 @default.
• W2078361523 cites W2046812792 @default.
• W2078361523 cites W2048525192 @default.
• W2078361523 cites W2050671544 @default.
• W2078361523 cites W2054282296 @default.
• W2078361523 cites W2057023399 @default.
• W2078361523 cites W2063764296 @default.
• W2078361523 cites W2066759468 @default.
• W2078361523 cites W2074869456 @default.
• W2078361523 cites W2076454433 @default.
• W2078361523 cites W2079628455 @default.
• W2078361523 cites W2086043328 @default.
• W2078361523 cites W2087252598 @default.
• W2078361523 cites W2088993406 @default.
• W2078361523 cites W2096192426 @default.
• W2078361523 cites W2098736996 @default.
• W2078361523 cites W2101156957 @default.
• W2078361523 cites W2115728783 @default.
• W2078361523 cites W2116541339 @default.
• W2078361523 cites W2119392695 @default.
• W2078361523 cites W2121473387 @default.
• W2078361523 cites W2122586715 @default.
• W2078361523 cites W2130270842 @default.
• W2078361523 cites W2140156016 @default.
• W2078361523 cites W2140390949 @default.
• W2078361523 cites W2144884836 @default.
• W2078361523 cites W2158052449 @default.
• W2078361523 cites W3023390007 @default.
• W2078361523 doi "https://doi.org/10.1016/j.pbb.2011.02.014" @default.
• W2078361523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21334364" @default.
• W2078361523 hasPublicationYear "2011" @default.
• W2078361523 type Work @default.
• W2078361523 sameAs 2078361523 @default.
• W2078361523 citedByCount "11" @default.
• W2078361523 countsByYear W20783615232012 @default.
• W2078361523 countsByYear W20783615232013 @default.
• W2078361523 countsByYear W20783615232014 @default.
• W2078361523 countsByYear W20783615232015 @default.
• W2078361523 countsByYear W20783615232016 @default.
• W2078361523 countsByYear W20783615232019 @default.
• W2078361523 countsByYear W20783615232021 @default.
• W2078361523 countsByYear W20783615232022 @default.
• W2078361523 countsByYear W20783615232023 @default.
• W2078361523 crossrefType "journal-article" @default.
• W2078361523 hasAuthorship W2078361523A5001237444 @default.
• W2078361523 hasAuthorship W2078361523A5090466401 @default.
• W2078361523 hasConcept C105795698 @default.
• W2078361523 hasConcept C126322002 @default.
• W2078361523 hasConcept C15744967 @default.
• W2078361523 hasConcept C169760540 @default.
• W2078361523 hasConcept C169900460 @default.
• W2078361523 hasConcept C170493617 @default.
• W2078361523 hasConcept C21963081 @default.
• W2078361523 hasConcept C2775968953 @default.
• W2078361523 hasConcept C2777397205 @default.
• W2078361523 hasConcept C2778851735 @default.
• W2078361523 hasConcept C2780598303 @default.
• W2078361523 hasConcept C33923547 @default.
• W2078361523 hasConcept C42219234 @default.
• W2078361523 hasConcept C53927964 @default.
• W2078361523 hasConcept C548259974 @default.
• W2078361523 hasConcept C66102695 @default.
• W2078361523 hasConcept C67018056 @default.
• W2078361523 hasConcept C71924100 @default.
• W2078361523 hasConceptScore W2078361523C105795698 @default.
• W2078361523 hasConceptScore W2078361523C126322002 @default.
• W2078361523 hasConceptScore W2078361523C15744967 @default.
• W2078361523 hasConceptScore W2078361523C169760540 @default.
• W2078361523 hasConceptScore W2078361523C169900460 @default.
• W2078361523 hasConceptScore W2078361523C170493617 @default.

• next