FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078364547> ?p ?o ?g. }

• W2078364547 endingPage "3189" @default.
• W2078364547 startingPage "3183" @default.
• W2078364547 abstract "Although nitric oxide (NO) is a bactericidal component of the macrophage’s innate response to intracellular infections such as tuberculosis (TB), prolonged inhalation of NO gas has little benefit in chemotherapy of TB. The impact of controlled release of NO through intracellular delivery of NO donors to macrophages infected in vitro with Mycobacterium tuberculosis (Mtb) was investigated. Inhalable microparticles (MP) were prepared by spray-drying. Isosorbide mononitrate (ISMN), sodium nitroprusside (SNP), and diethylenetriamine nitric oxide adduct (DETA/NO) were incorporated in poly(lactic-co-glycolic acid) (PLGA) with encapsulation efficiencies of >90% to obtain MP yields of ∼70%. The mass median aerodynamic diameter (MMAD) of the MP was 2.2–2.4 μm within geometric standard deviations (GSD) of ≤0.1 μm. MP were phagocytosed by THP-1 derived macrophages in culture and significantly (P < 0.05) sustained NO secretion into culture supernatant from 6 to 72 h in comparison to equivalent amounts of drugs in solution. Significantly (P < 0.05) higher dose-dependent killing of intracellular Mtb by MP compared to equivalent amounts of drugs in solution was observed on estimation of colony forming units (CFU) surviving 24 h after exposure to drugs or MP. The cytotoxicity of MP toward macrophages was lower than that of dissolved drugs. It was concluded that inhalable MP can target NO donors to the macrophage, control NO release in the macrophage cytosol, and reduce Mtb CFU by up to 3-log in 24 h, at doses that are much lower than those required for cardiovascular effects." @default.
• W2078364547 created "2016-06-24" @default.
• W2078364547 creator A5000959196 @default.
• W2078364547 creator A5006595070 @default.
• W2078364547 creator A5016712151 @default.
• W2078364547 creator A5022961880 @default.
• W2078364547 creator A5038032543 @default.
• W2078364547 creator A5071290143 @default.
• W2078364547 creator A5087888100 @default.
• W2078364547 date "2012-09-27" @default.
• W2078364547 modified "2023-09-23" @default.
• W2078364547 title "Inhalable Microparticles Containing Nitric Oxide Donors: Saying NO to Intracellular <i>Mycobacterium tuberculosis</i>" @default.
• W2078364547 cites W1578514570 @default.
• W2078364547 cites W1589577719 @default.
• W2078364547 cites W1939948552 @default.
• W2078364547 cites W1971938421 @default.
• W2078364547 cites W1972501915 @default.
• W2078364547 cites W1976952556 @default.
• W2078364547 cites W1982324466 @default.
• W2078364547 cites W1986715619 @default.
• W2078364547 cites W2000177095 @default.
• W2078364547 cites W2002047195 @default.
• W2078364547 cites W2004123015 @default.
• W2078364547 cites W2032548370 @default.
• W2078364547 cites W2034769077 @default.
• W2078364547 cites W2047049033 @default.
• W2078364547 cites W2055975025 @default.
• W2078364547 cites W2060136006 @default.
• W2078364547 cites W2081485204 @default.
• W2078364547 cites W2101559550 @default.
• W2078364547 cites W2103177915 @default.
• W2078364547 cites W2115262431 @default.
• W2078364547 cites W2115665082 @default.
• W2078364547 cites W2120925270 @default.
• W2078364547 cites W2131902476 @default.
• W2078364547 cites W2138197340 @default.
• W2078364547 cites W2143478697 @default.
• W2078364547 cites W2144134116 @default.
• W2078364547 cites W2153819765 @default.
• W2078364547 cites W2157782849 @default.
• W2078364547 cites W2161034058 @default.
• W2078364547 cites W2163510491 @default.
• W2078364547 cites W2165195219 @default.
• W2078364547 cites W301527467 @default.
• W2078364547 doi "https://doi.org/10.1021/mp300269g" @default.
• W2078364547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22978290" @default.
• W2078364547 hasPublicationYear "2012" @default.
• W2078364547 type Work @default.
• W2078364547 sameAs 2078364547 @default.
• W2078364547 citedByCount "34" @default.
• W2078364547 countsByYear W20783645472013 @default.
• W2078364547 countsByYear W20783645472014 @default.
• W2078364547 countsByYear W20783645472015 @default.
• W2078364547 countsByYear W20783645472016 @default.
• W2078364547 countsByYear W20783645472017 @default.
• W2078364547 countsByYear W20783645472018 @default.
• W2078364547 countsByYear W20783645472019 @default.
• W2078364547 countsByYear W20783645472020 @default.
• W2078364547 countsByYear W20783645472021 @default.
• W2078364547 countsByYear W20783645472022 @default.
• W2078364547 crossrefType "journal-article" @default.
• W2078364547 hasAuthorship W2078364547A5000959196 @default.
• W2078364547 hasAuthorship W2078364547A5006595070 @default.
• W2078364547 hasAuthorship W2078364547A5016712151 @default.
• W2078364547 hasAuthorship W2078364547A5022961880 @default.
• W2078364547 hasAuthorship W2078364547A5038032543 @default.
• W2078364547 hasAuthorship W2078364547A5071290143 @default.
• W2078364547 hasAuthorship W2078364547A5087888100 @default.
• W2078364547 hasConcept C105702510 @default.
• W2078364547 hasConcept C109316439 @default.
• W2078364547 hasConcept C142724271 @default.
• W2078364547 hasConcept C178790620 @default.
• W2078364547 hasConcept C185592680 @default.
• W2078364547 hasConcept C202751555 @default.
• W2078364547 hasConcept C2776954882 @default.
• W2078364547 hasConcept C2777975735 @default.
• W2078364547 hasConcept C2779244956 @default.
• W2078364547 hasConcept C2779610285 @default.
• W2078364547 hasConcept C2781069245 @default.
• W2078364547 hasConcept C519581460 @default.
• W2078364547 hasConcept C55493867 @default.
• W2078364547 hasConcept C71924100 @default.
• W2078364547 hasConcept C79879829 @default.
• W2078364547 hasConcept C86803240 @default.
• W2078364547 hasConcept C89423630 @default.
• W2078364547 hasConcept C98274493 @default.
• W2078364547 hasConceptScore W2078364547C105702510 @default.
• W2078364547 hasConceptScore W2078364547C109316439 @default.
• W2078364547 hasConceptScore W2078364547C142724271 @default.
• W2078364547 hasConceptScore W2078364547C178790620 @default.
• W2078364547 hasConceptScore W2078364547C185592680 @default.
• W2078364547 hasConceptScore W2078364547C202751555 @default.
• W2078364547 hasConceptScore W2078364547C2776954882 @default.
• W2078364547 hasConceptScore W2078364547C2777975735 @default.
• W2078364547 hasConceptScore W2078364547C2779244956 @default.
• W2078364547 hasConceptScore W2078364547C2779610285 @default.
• W2078364547 hasConceptScore W2078364547C2781069245 @default.
• W2078364547 hasConceptScore W2078364547C519581460 @default.

• next