FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078366144> ?p ?o ?g. }

• W2078366144 endingPage "273" @default.
• W2078366144 startingPage "270" @default.
• W2078366144 abstract "Histone deacetylases (HDACs) have emerged as attractive targets in anticancer drug development. To date, a number of HDAC inhibitors have been developed and most of them are hydroxamic acid derivatives, typified by suberoylanilide hydroxamic acid (SAHA). Not surprisingly, structural information that can greatly enhance the design of novel HDAC inhibitors is so far only available for hydroxamic acids in complex with HDAC or HDAC-like enzymes. Here, the first structure of an enzyme complex with a nonhydroxamate HDAC inhibitor is presented. The structure of the trifluoromethyl ketone inhibitor 9,9,9-trifluoro-8-oxo-N-phenylnonanamide in complex with bacterial FB188 HDAH (histone deacetylase-like amidohydrolase from Bordetella/Alcaligenes strain FB188) has been determined. HDAH reveals high sequential and functional homology to human class 2 HDACs and a high structural homology to human class 1 HDACs. Comparison with the structure of HDAH in complex with SAHA reveals that the two inhibitors superimpose well. However, significant differences in binding to the active site of HDAH were observed. In the presented structure the O atom of the trifluoromethyl ketone moiety is within binding distance of the Zn atom of the enzyme and the F atoms participate in interactions with the enzyme, thereby involving more amino acids in enzyme-inhibitor binding." @default.
• W2078366144 created "2016-06-24" @default.
• W2078366144 creator A5008750279 @default.
• W2078366144 creator A5012897382 @default.
• W2078366144 creator A5031085718 @default.
• W2078366144 creator A5071195474 @default.
• W2078366144 creator A5079616283 @default.
• W2078366144 creator A5089962199 @default.
• W2078366144 date "2007-03-23" @default.
• W2078366144 modified "2023-10-01" @default.
• W2078366144 title "Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor" @default.
• W2078366144 cites W1521025514 @default.
• W2078366144 cites W1636945110 @default.
• W2078366144 cites W1970383032 @default.
• W2078366144 cites W1971621147 @default.
• W2078366144 cites W1977922402 @default.
• W2078366144 cites W1991908993 @default.
• W2078366144 cites W2002816714 @default.
• W2078366144 cites W2003912645 @default.
• W2078366144 cites W2038840577 @default.
• W2078366144 cites W204164459 @default.
• W2078366144 cites W2071947905 @default.
• W2078366144 cites W2078454854 @default.
• W2078366144 cites W2088783750 @default.
• W2078366144 cites W2100338355 @default.
• W2078366144 cites W2114367386 @default.
• W2078366144 cites W2114468318 @default.
• W2078366144 cites W2127587233 @default.
• W2078366144 cites W2134009718 @default.
• W2078366144 cites W2135085078 @default.
• W2078366144 cites W2135830745 @default.
• W2078366144 cites W2149419525 @default.
• W2078366144 cites W2151105846 @default.
• W2078366144 cites W2160665967 @default.
• W2078366144 cites W2952410637 @default.
• W2078366144 doi "https://doi.org/10.1107/s1744309107012377" @default.
• W2078366144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2330214" @default.
• W2078366144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17401192" @default.
• W2078366144 hasPublicationYear "2007" @default.
• W2078366144 type Work @default.
• W2078366144 sameAs 2078366144 @default.
• W2078366144 citedByCount "29" @default.
• W2078366144 countsByYear W20783661442012 @default.
• W2078366144 countsByYear W20783661442013 @default.
• W2078366144 countsByYear W20783661442015 @default.
• W2078366144 countsByYear W20783661442016 @default.
• W2078366144 countsByYear W20783661442017 @default.
• W2078366144 countsByYear W20783661442018 @default.
• W2078366144 countsByYear W20783661442019 @default.
• W2078366144 countsByYear W20783661442020 @default.
• W2078366144 countsByYear W20783661442021 @default.
• W2078366144 countsByYear W20783661442022 @default.
• W2078366144 countsByYear W20783661442023 @default.
• W2078366144 crossrefType "journal-article" @default.
• W2078366144 hasAuthorship W2078366144A5008750279 @default.
• W2078366144 hasAuthorship W2078366144A5012897382 @default.
• W2078366144 hasAuthorship W2078366144A5031085718 @default.
• W2078366144 hasAuthorship W2078366144A5071195474 @default.
• W2078366144 hasAuthorship W2078366144A5079616283 @default.
• W2078366144 hasAuthorship W2078366144A5089962199 @default.
• W2078366144 hasBestOaLocation W20783661442 @default.
• W2078366144 hasConcept C104317684 @default.
• W2078366144 hasConcept C169627665 @default.
• W2078366144 hasConcept C181199279 @default.
• W2078366144 hasConcept C185592680 @default.
• W2078366144 hasConcept C2776281265 @default.
• W2078366144 hasConcept C2776568683 @default.
• W2078366144 hasConcept C2778305200 @default.
• W2078366144 hasConcept C2779485144 @default.
• W2078366144 hasConcept C41183919 @default.
• W2078366144 hasConcept C55493867 @default.
• W2078366144 hasConcept C64927066 @default.
• W2078366144 hasConcept C71240020 @default.
• W2078366144 hasConceptScore W2078366144C104317684 @default.
• W2078366144 hasConceptScore W2078366144C169627665 @default.
• W2078366144 hasConceptScore W2078366144C181199279 @default.
• W2078366144 hasConceptScore W2078366144C185592680 @default.
• W2078366144 hasConceptScore W2078366144C2776281265 @default.
• W2078366144 hasConceptScore W2078366144C2776568683 @default.
• W2078366144 hasConceptScore W2078366144C2778305200 @default.
• W2078366144 hasConceptScore W2078366144C2779485144 @default.
• W2078366144 hasConceptScore W2078366144C41183919 @default.
• W2078366144 hasConceptScore W2078366144C55493867 @default.
• W2078366144 hasConceptScore W2078366144C64927066 @default.
• W2078366144 hasConceptScore W2078366144C71240020 @default.
• W2078366144 hasIssue "4" @default.
• W2078366144 hasLocation W20783661441 @default.
• W2078366144 hasLocation W20783661442 @default.
• W2078366144 hasLocation W20783661443 @default.
• W2078366144 hasLocation W20783661444 @default.
• W2078366144 hasOpenAccess W2078366144 @default.
• W2078366144 hasPrimaryLocation W20783661441 @default.
• W2078366144 hasRelatedWork W1975602880 @default.
• W2078366144 hasRelatedWork W1995545479 @default.
• W2078366144 hasRelatedWork W2011419862 @default.
• W2078366144 hasRelatedWork W2022420750 @default.
• W2078366144 hasRelatedWork W2025054399 @default.
• W2078366144 hasRelatedWork W2053605636 @default.

• next